Polymer composition, article, medical device, article production method, and cell cluster production method

Patent metadata

Field	Value
Publication number	US-10774165-B2
Application number	US-201615749542-A
Country	US
Kind code	B2
Filing date	Aug 4, 2016
Priority date	Aug 4, 2015
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

The present invention relates to: a polymer composition; an article; a medical device; an article production method; and a cell cluster production method. The polymer composition contains a polymer having the following repeating units (A) and (B) and is one selected from the group consisting of a medical device composition, a cell adhesion inhibitor, and a silicone substrate treatment composition:
(A) a hydrophilic repeating unit; and (B) a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is constituted by an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms.

First claim

The invention claimed is:

1. An article comprising, on at least a part of a surface thereof, a polymer having repeating units (A) and (B),
wherein said article is one selected from the group consisting of a medical device, a cell culture equipment, and a silicone substrate;
(A) is a hydrophilic repeating unit; and
(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms, and
wherein the article is a silicone substrate which has a microchannel.

2. The article according to claim 1 ,
wherein said repeating unit (A) is at least one selected from the group consisting of a repeating unit (A-1) represented by Formula (1), a repeating unit (A-2) represented by Formula (2), a repeating unit (A-3) represented by Formula (3), a repeating unit (A-4) represented by Formula (4), a repeating unit (A-5) represented by Formula (5), a repeating unit (A-6) represented by Formula (6), an anionic repeating unit (A-7), and a repeating unit (A-8) represented by Formula (8):

wherein, R 1 represents an alkylene group having 2 to 4 carbon atoms; R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 represents a hydrogen atom or a methyl group; R 4 represents —O—, *—(C═O)—O—, *—(C═O)—NR 5 —, *—NR 5 —(C═O)— where R 5 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group; and n represents a value of 2 to 100;

wherein, R 6 represents a hydrogen atom or a methyl group; R 7 represents an alkylene group having 2 to 4 carbon atoms; R 8 represents an alkylene group having 1 to 10 carbon atoms; R 9 , R 10 and R 11 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 8 carbon atoms; and q represents a value of 1 to 10;

wherein, R 12 represents a hydrogen atom or a methyl group; and R 13 and R 14 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or hydroxyalkyl group;

wherein, R 15 represents a hydrogen atom or a methyl group; and R 16 and R 17 each independently represent an alkylene group having 1 to 3 carbon atoms;

wherein, R 18 represents an alkylene group having 1 to 5 carbon atoms;

wherein, Y represents —(C═O)O − , —(O═S═O)O − , —O(O═S═O)O − , —(S═O)O − , —O(S═O)O − , —OP(═O)(OR 24 )O − , —OP(═O)(R 24 )O − , —P(═O)(OR 24 )O − , or —P(═O)(R 24 )O − where R 24 represents an alkyl group having 1 to 3 carbon atoms; R 19 represents a hydrogen atom or a methyl group; R 2 ° represents a divalent organic group having 1 to 10 carbon atoms; R 21 and R 22 each independently represent a hydrocarbon group having 1 to 10 carbon atoms; and R 23 represents a divalent organic group having 1 to 10 carbon atoms; and

wherein, R 25 represents a hydrogen atom or a methyl group; R 26 represents —O—, *—(C═O)—O—, *—(C═O)—NR 31 —, *—NR 31 —(C═O)— where R 31 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 25 in the Formula (8), or a phenylene group; R 27 represents a divalent organic group having 1 to 10 carbon atoms; and R 28 , R 29 and R 30 each independently represent a hydrocarbon group having 1 to 10 carbon atoms, wherein the repeating unit (A-8) has a counter ion.

3. The article according to claim 2 , wherein in Formula (1), R 4 represents *—(C═O)—O— and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group.

4. The article according to claim 1 , wherein said repeating unit (B) is a repeating unit derived from a monomer having an ethylenically unsaturated bond.

5. The article according to claim 1 , wherein said repeating unit (B) is represented by Formula (b2):

wherein, R 32 represents an alkylene group having 2 to 4 carbon atoms; R 33 represents an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms; R 34 represents a hydrogen atom or a methyl group; R 35 represents —O—, **—(C═O)—O—, **—(C═O)—NR 36 —, **—NR 36 —(C═O)— where R 36 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and ** represents a position at which the group is bound to a carbon atom bound with R 34 in the Formula (b2), or a phenylene group; and m represents a value of 2 to 100.

6. The article according to claim 1 , wherein said polymer further comprises at least one repeating unit (C) selected from the group consisting of a repeating unit (C-1) represented by Formula (c1) and a repeating unit (C-2) having a group represented by Formula (c2) at a side chain terminal:

wherein, R 37 represents a hydrogen atom or a methyl group; R 38 represents —O—, ***—(C═O)—O—, ***—(C═O)—NR 40 —, ***—NR 40 —(C═O)— where R 40 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and *** represents a position at which the group is bound to a carbon atom bound with R 37 in the Formula (c1), or a phenylene group; and R 39 represents a hydrocarbon group having 4 to 30 carbon atoms; and

wherein, R 41 represents a divalent organic group having 1 to 10 carbon atoms; R 42 and R 43 each independently represent an organic group having 1 to 10 carbon atoms; R 44 , R 45 and R 46 each independently represent —OSi(R 49 ) 3 where each R 49 independently represents a hydrogen atom or an organic group having 1 to 8 carbon atoms, or an organic group having 1 to 10 carbon atoms; and r represents a value of 0 to 200.

7. The article according to claim 1 , wherein said polymer is soluble in water.

8. A method of producing an article selected from the group consisting of a medical device, a cell culture equipment and a silicone substrate, said method comprising
arranging a polymer having repeating units (A) and (B) on at least a part of a surface of the article,
wherein
(A) is a hydrophilic repeating unit; and
(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms,
wherein the article is a silicone substrate which has a microchannel.

9. The method according to claim 8 ,
wherein
(A) is a hydrophilic repeating unit; and
(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl g

Assignees

• Jsr Corp
• Jsr Life Sciences Corp

Inventors

• Hyuugaji Satoshi

Classifications

• C08F220/286 Primary

  and containing polyethylene oxide in the alcohol moiety, e.g. methoxy polyethylene glycol (meth)acrylate · CPC title

• C08F220/365

  containing further carboxylic moieties · CPC title

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title