Crystal of reduced glutathione and method for producing same

Patent metadata

Field	Value
Publication number	US-10774109-B2
Application number	US-201716083483-A
Country	US
Kind code	B2
Filing date	Mar 10, 2017
Priority date	Mar 17, 2016
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 μm or more.

First claim

The invention claimed is:

1. A crystal of reduced glutathione, wherein the crystal has an average crystal length, an average crystal width, and an average crystal thickness, and the average crystal thickness is smaller than the average crystal length and the average crystal width, and wherein the average crystal thickness is 10 μm to 40 μm.

2. The crystal according to claim 1 , wherein the crystal has a ratio L/W of the average crystal length L to the average crystal width W of 6.0 or less.

3. The crystal according to claim 2 , wherein the crystal has a loose specific volume of 1.0 mL/g to 2.5 mL/g.

4. The crystal according to claim 3 , wherein the crystal has a dense specific volume of 0.8 mL/g to 2.0 mL/g.

5. The crystal according to claim 4 , wherein the crystal has an angle of repose of 30° to 50°.

6. The crystal according to claim 5 , wherein the crystal has an angle of rupture of 30° to 45°.

7. The crystal according to claim 6 , wherein the crystal of reduced glutathione is an α crystal.

8. The crystal according to claim 1 , wherein the crystal has a loose specific volume of 1.0 mL/g to 2.5 mL/g.

9. The crystal according to claim 1 , wherein the crystal has a dense specific volume of 0.8 mL/g to 2.0 mL/g.

10. The crystal according to claim 1 , wherein the crystal has an angle of repose of 30° to 50°.

11. The crystal according to claim 1 , wherein the crystal has an angle of rupture of 30° to 45°.

12. The crystal according to claim 1 , wherein the crystal of reduced glutathione is an α crystal.

Assignees

• Kyowa Hakko Bio Co Ltd

Inventors

• Fukumoto Kazunari
• Iguchi Maya
• Nagano Hiroshi

Classifications

• C07K5/0215 Primary

  containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu · CPC title

• A61K38/06

  Tripeptides · CPC title

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title

• C30B29/58

  Macromolecular compounds · CPC title

• A61P39/02

  Antidotes · CPC title