System for blending solutions

Patent metadata

Field	Value
Publication number	US-10773185-B2
Application number	US-201515533551-A
Country	US
Kind code	B2
Filing date	Dec 17, 2015
Priority date	Dec 17, 2014
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

A system for blending solutions and a buffer solution is disclosed. In this system a switch valve is present capable of flowing one or more solutions, a low pressure pump for pumping the one or more solutions through the switch valve and a T-joint capable of receiving the one or more solutions through the low pressure pump and blending the one or more solutions with a buffer solution. A high pressure pump is present for collecting a blended solution.

First claim

I claim:

1. A system for blending solutions, the system comprising:
a first container holding at least one solution;
a second container holding a buffer solution;
a switch valve capable of flowing the at least one solution, wherein the switch valve is fluidically connected to the first container and to the second container;
a low pressure pump fluidically connected to the switch valve for pumping, the at least one solution through the switch valve;
a high pressure pump for collecting a blended solution comprising the at least one solution and the buffer solution;
a T-joint placed between and fluidically connected to the low pressure pump and the high pressure pump, the T- joint being fluidically coupled to the first container through the low pressure pump to receive the at least one solution through the low pressure pump, wherein the T-joint is fluidically connected to the second container holding the buffer solution through at least one direct connection to blend the at least one solution with the buffer solution to form the blended solution,
wherein the switch valve is configured to allow the buffer solution to flow from the second container through the low pressure pump, and
wherein the low pressure pump is configured to, pump the buffer solution from the second container through the switch valve to the T-joint.

2. The system of claim 1 , wherein the at least one solution comprises at least one of an acid, a base and a salt solution.

3. The system of claim 1 , further comprising a control system configured to: control operation of the low pressure pump for supplying the at least one solution and control the functioning of the switch valve capable of flowing the at least one solution.

4. The system of claim 3 , wherein the control system is configured to control the flow rate of the at least one solution supplied by the at least one low pressure pump, the flow rate of the at least one solution determines concentration of the blended solution.

5. The system of claim 1 , further comprising at least one sensor configured to measure characteristics of the blended solution received at the high pressure pump.

6. The system of claim 5 , wherein a sensor of the at least one sensor is configured to measure a conductivity associated with the blended solution.

7. The system of claim 5 , wherein a sensor of the at least one sensor is configured to measure a pH level associated with the buffer solution.

8. The system of claim 1 , further comprising a sensor between and fluidically connected to the low pressure pump and the high pressure pump.

9. A chromatography system comprising:
a first container holding at least one solution;
a second container holding a buffer solution;
a switch valve capable of flowing at least one solution, wherein the switch valve is fluidically connected to the first container and to the second container;
a low pressure pump fiuidically connected to the switch valve for pumping the at least one solution through the switch valve;
a high pressure pump for collecting and delivering a blended solution comprising the at least one solution and the buffer solution to a chromatography column;
a T-joint placed between and fluidically connected to the low pressure pump and the high pressure pump, the T-joint capable of receiving the at least one solution through the low pressure pump, wherein the T-joint is fluidically connected to the container holding the buffer solution through at least one direct connection to blend the at least one solution with the buffer solution to form the blended solution, and
wherein the switch valve is configured to allow the buffer solution to flow from the second container through the low pressure pump, and
wherein the low pressure pump is configured to pump the buffer solution from the second container through the switch valve to the T-joint.

10. The chromatography system of claim 9 , wherein the at least one solution comprises at least one of an acid, a base and a salt solution.

11. The chromatography system of claim 9 , further comprising a control system configured to: control operation of the low pressure pump for supplying the at least one solution and control the functioning of the switch valve capable of flowing the at least one solution.

12. The chromatography system of claim 11 , wherein the control the flow rate of the at least one solution supplied by the at least one low pressure pump, the flow rate of the at least one solution determines concentration of the blended solution.

13. The chromatography system of claim 9 , further comprising at least one sensor configured to measure characteristics of the blended solution received at the high pressure pump.

14. The chromatography system of claim 13 , wherein a sensor of the at least one sensor is configured to measure a conductivity associated with the blended solution.

15. The chromatography system of claim 13 , wherein a sensor of the at least one sensor is configured to measure a pH level associated with the blended solution.

16. The system of claim 9 , further comprising a sensor between and connected to the low pressure pump and the high pressure pump.

Assignees

• Ge Healthcare Bio Sciences Ab

Inventors

• Olovsson Bjorn Markus

Classifications

• B01F35/2217

  Volume of at least one component to be mixed · CPC title

• B01F35/71805

  using valves, gates, orifices or openings · CPC title

• B01F35/2133

  Electrical conductivity or dielectric constant of the mixture · CPC title

• B01F23/45

  using flow mixing · CPC title

• G01N30/8658

  Optimising operation parameters · CPC title