Direct magnetic imaging with metamaterial for focusing and thermal ablation using SPION nanoparticles for cancer diagnosis and treatment

Patent metadata

Field	Value
Publication number	US-10773095-B2
Application number	US-201214007179-A
Country	US
Kind code	B2
Filing date	Jun 21, 2012
Priority date	Jun 21, 2011
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

Devices and methods for identifying and destroying cancer cells are disclosed. Devices and methods may relate to techniques of imaging and/or irradiating cells bearing a plurality of surface-modified superparamagnetic iron oxide nanoparticles (SPIONs) therein. Imaging can be realized with a magnetic imaging device that generates an imaging magnetic field. A magnetic field associated with the SPION-bearing cancer cells and resulting from imaging, can be detected with a detection device. Irradiation can be realized with a magnetic field emission device that generates an irradiation magnetic field such that the SPIONs in the SPION-bearing cells are heated as a result of said magnetic field, thereby killing the SPION-bearing cells. The magnetic imaging device may be used as the magnetic field emission device. The magnetic fields produced for imaging and/or irradiating, as well as the associated magnetic field, can be focused using one or more magnetic metalens devices.

First claim

We claim:

1. An apparatus for non-surgical thermal ablation treatment, comprising:
a magnetic field detector; and
a magnetic imaging device having a first magnetic metalens device tunable between an irradiating arrangement and an imaging arrangement and a second magnetic metalens device;
wherein the first magnetic metalens device comprising an isotropic metalens;
wherein the isotropic metalens comprising a periodic array of subwavelength cubic unit cells;
wherein the magnetic imaging device is configured for imaging cancer cells that have absorbed superparamagnetic iron oxide nanoparticles (SPIONs);
wherein said first magnetic metalens device is configured to focus a magnetic field, at the SPION-bearing cells, generated by the magnetic imaging device, said first magnetic metalens device comprising a matched resonant coil operating in conjunction with the metalens, said coil being equipped with a matching network that includes at least a series capacitor, and a second matched resonant coil, where the matched resonant coil is a transmitting coil and the second matched resonant coil is a receiving coil:
wherein an associated magnetic field associated with the SPION-bearing cells is configured to be detected by the magnetic field detector;
wherein the magnetic imaging device is configured to generate an irradiating magnetic field at a frequency of 500 kHz and at an amplitude of up to 10 kA/m for irradiating the SPION-bearing cells;
wherein the SPIONs are heated as a result of the magnetic field generated by the magnetic imaging device, thereby killing the SPION-bearing cells; and
wherein the first magnetic metalens device configured to focus the magnetic field generated by the magnetic imaging device during at least one of imaging and irradiation by the magnetic imaging device, and the second magnetic metalens device configured to focus the irradiating magnetic field.

2. The apparatus of claim 1 , where the first magnetic metalens device focuses said associated magnetic field for detection by the magnetic field detector.

3. The apparatus of claim 1 , further comprising a third magnetic metalens device, where the first magnetic metalens device focuses the imaging magnetic field, and the third magnetic metalens device focuses the associated magnetic field for detection by the magnetic field detector.

4. The apparatus of claim 1 , wherein each cubic unit cell of the isotropic metalens includes a conducting loop and capacitor on each of six inner faces of the cell.

5. The apparatus of claim 1 , where the matching network further includes a tapered microstrip that transforms an impedance of the resonant coil.

6. The apparatus of claim 1 , where the matched resonant coil is a transmitting coil.

7. The apparatus of claim 1 , further comprising a plurality of surface-modified SPIONs configured for absorption by cells of an organism, said SPIONs being administered to the organism to create said SPION-bearing cells.

8. The apparatus of claim 1 , where the magnetic imaging device is a magnetic resonance imaging device (MRI).

9. The apparatus of claim 1 , where the SPIONs are configured to have the same diameter.

10. The apparatus of claim 1 , where the SPIONs comprise iron oxide nanoparticles having a large magnetic moment.

11. The apparatus of claim 1 , wherein the magnetic metalens device is configured to have n=−1 for focusing the magnetic field.

12. The apparatus of claim 1 , wherein a design of the magnetic metalens device involves crossed wires instead of split ring resonators.

13. The apparatus of claim 1 , wherein the magnetic imaging device and the metalens device are disposed outside a body of a patient undergoing cancer treatment.

Assignees

• Drake Christina
• Baleine Clara
• Lockheed Corp

Inventors

• Drake Christina
• Baleine Clara

Classifications

• A61B5/055 Primary

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61B90/39

  Markers, e.g. radio-opaque or breast lesions markers · CPC title

• A61B18/04

  by heating (by applying electromagnetic radiation A61B18/18) · CPC title

• A61N2/02 Primary

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title