Neural electrode array attachment

Patent metadata

Field	Value
Publication number	US-10773075-B2
Application number	US-201815925953-A
Country	US
Kind code	B2
Filing date	Mar 20, 2018
Priority date	Mar 22, 2017
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

An electrode cuff for placement around a peripheral nerve can include one or more protrusions extending from a tissue-contacting surface of the electrode cuff. A protrusion can include one or more electrodes and can have a blunt distal end. The protrusion(s) can be driven into the nerve using a driving tool designed to apply mechanical oscillations and/or swift mechanical force to the electrode cuff. The mechanical oscillations and/or swift mechanical force can insert the blunt distal ends of the protrusions into the nerve without damaging fascicles within the nerve. During implantation, a sensor associated with the driving tool and/or the electrode cuff can provide dynamic feedback to a controller for controlling the driving tool. The sensor may detect pressure, temperature, acoustic activity, and/or electrical activity to indicate when the protrusions have pierced the epineurium, allowing the controller to cease the driving tool and thus avoid damage to the fascicles.

First claim

What is claimed is:

1. An electrode placement system, comprising:
an electrode cuff comprising:
a substrate having a tissue-facing surface curved in a concave shape;
at least one electrode protrusion extending from the tissue-facing surface and including one or more individual electrodes thereon, each of the at least one electrode protrusion including a blunt distal end, wherein at least part of each of the one or more individual electrodes are exposed on the blunt distal end; and

a driving tool positioned and configured to apply mechanical force to the substrate, the driving tool comprising an oscillating driver, a pneumatic driver, or both, wherein the driving tool is integrated into the electrode cuff.

2. The electrode placement system of claim 1 , wherein the driving tool includes the oscillating driver for delivering oscillating mechanical force to the substrate of the electrode cuff.

3. The electrode placement system of claim 2 , wherein the oscillating driver includes an ultrasonic transducer.

4. The electrode placement system of claim 1 , wherein the driving tool includes the pneumatic driver configured to apply a swift mechanical force to the substrate of the electrode cuff.

5. The electrode placement system of claim 4 , wherein the swift mechanical force is a force greater than 0.5 N.

6. The electrode placement system of claim 4 , wherein the swift mechanical force is applied for less than 1 s.

7. The electrode placement system of claim 4 , wherein the swift mechanical force exerts a force on the substrate of the electrode cuff that drives the electrode protrusions to penetrate a depth ranging from 2 μm to 20 μm of the nerve.

8. The electrode placement system of claim 4 , wherein the swift mechanical force is a force greater than 0.5 N that is applied for less than 1 s.

9. The electrode placement system of claim 1 , wherein the pneumatic driver is configured to receive a source of compressed air to provide the mechanical force.

10. The electrode placement system of claim 1 , further comprising:
a sensor coupled to the at least one electrode protrusion to measure an insertion-indicative value, the insertion-indicative value being indicative of whether the at least one electrode protrusion has penetrated at least part of the nerve; and
a controller coupled to the sensor and the driving tool to control the driving tool in response to the measured value.

11. The electrode placement system of claim 10 , wherein the sensor comprises an electrical sensor, a mechanical sensor, a temperature sensor, or an acoustic sensor.

12. The electrode placement system of claim 10 , wherein the driving tool includes at least one pneumatic actuator, and wherein the sensor is a pressure sensor for detecting pneumatic pressure applied to the at least one pneumatic actuator.

13. A method of applying an electrode cuff to target nerve, comprising:
providing an electrode cuff comprising:
a substrate having a tissue-facing surface curved in a concave shape; and
at least one electrode protrusion extending from the tissue-facing surface and including one or more individual electrodes thereon, the at least one electrode protrusion includes a blunt distal end, wherein at least part of the one or more individual electrodes are exposed on the blunt distal end; and

positioning the tissue-facing surface of the substrate against a nerve; and
actuating a driving tool to apply a mechanical force to the electrode cuff to pierce the at least one protrusion into a nerve, wherein the driving tool is an oscillating driver, a pneumatic driver, or both, wherein the driving tool is integrated into the electrode cuff.

14. The method of claim 13 , further comprising:
measuring an insertion-indicative value, the insertion-indicative value being indicative of whether the at least one electrode protrusion has penetrated at least part of the nerve;
wherein actuating the driving tool further comprises dynamically controlling the mechanical force applied to the substrate in response to the measured insertion-indicative value.

15. The method of claim 13 , wherein the driving tool includes the oscillating driver, wherein actuating the oscillating driver comprises applying oscillating mechanical force to the electrode cuff to pierce the at least one protrusion into the nerve.

16. The method of claim 13 , wherein the driving tool includes the pneumatic driver, wherein actuating the pneumatic driver comprises applying swift mechanical force to the electrode cuff to pierce the at least one protrusion into the nerve.

17. The method of claim 16 , wherein the swift mechanical force is a force greater than 0.5 N that is applied for less than 1 s.

Assignees

• Verily Life Sciences Llc

Inventors

• Pepin Brian
• Cong Peng
• Shah Kedar
• Sabesan Shivkumar

Classifications

• A61N1/05 Primary

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61N1/36

  for stimulation · CPC title

• A61N1/0558 Primary

  Anchoring or fixation means therefor · CPC title

• A61N1/0556

  Cuff electrodes · CPC title

• A61N1/08

  Arrangements or circuits for monitoring, protecting, controlling or indicating {(for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925)} · CPC title