Synthesis of nitric oxide gas for inhalation

Patent metadata

Field	Value
Publication number	US-10773047-B2
Application number	US-201414777084-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

First claim

What is claimed is:

1. A method comprising:
collecting information related to one or more conditions of a respiratory system associated with a patient;
determining one or more control parameters based on the collected information, the one or more control parameters being determined by a controller in electrical communication with at least one sensor for collecting the information related to one or more condition of the respiratory system, the one or more conditions comprising an inspiration event of the patient; and
initiating a series of electric arcs external to the patient to generate nitric oxide (NO) based on the determined control parameters, the series of electric arcs being initiated by a periodic pulse train that includes pulse groups separated by a period without pulsing and with the amount of time between pulses in the pulse groups being less than the amount of time between the pulse groups;
wherein the pulse groups in the pulse train are effective to decrease the amount of NO 2 generated for a given amount of NO.

2. The method of claim 1 , wherein the conditions associated with the respiratory system further include one or more of the oxygen concentration of a reactant gas, a flow rate of the reactant gas, a volume and timing of the inspiration event, the oxygen concentration of a product gas, the nitric oxide concentration of the product gas, the nitrogen dioxide concentration of the product gas, the ozone concentration of the product gas, the nitric oxide concentration of an inhaled gas, and the nitrogen dioxide concentration of the inhaled gas.

3. The method of claim 1 , wherein the volume and timing of the inspiration event is received from a ventilator.

4. The method of claim 1 , wherein a pulse train initiates the series of electric arcs, the pulse train including pulse groups having pulses with different pulse widths.

5. The method of claim 1 , wherein the series of electric arcs generates a reduced level of at least one of nitrogen dioxide or ozone.

6. The method of claim 5 , wherein the reduced level of nitrogen dioxide is further reduced by a scavenger comprising one or more of KaOH, CaOH, CaC03, and NaOH.

7. The method of claim 5 , wherein the reduced level of nitrogen dioxide has a concentration that is less than 20% of a concentration of the generated nitric oxide.

8. The method of claim 1 , wherein the series of electric arcs is generated by electrodes comprising at least one of a noble metal, iridium, or nickel.

9. An apparatus comprising:
a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas;
a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, wherein the one or more conditions include an inspiration event of the patient;
a controller for determining one or more control parameters based on the collected information, the controller being in electrical communication with the sensor to deliver a series of electrical pulses to one or more pairs of electrodes, the series of electric pulses forming a periodic pulse train that includes pulse groups separated by a period without pulsing and with the amount of time between pulses in the pulse groups being less than the amount of time between the pulse groups; and
one or more pairs of electrodes positioned inside the chamber for producing a series of electric arcs external to the patient based on the series of electrical pulses to generate nitric oxide based on the determined control parameters;
wherein the pulse groups in the pulse train are effective to decrease the amount of NO 2 generated for a given amount of NO.

10. The apparatus of claim 9 , wherein the conditions associated with the respiratory system further include one or more of the oxygen concentration of the reactant gas, a flow rate of the reactant gas, a volume and timing of the inspiration event, the oxygen concentration of the product gas, the nitric oxide concentration of the product gas, the nitrogen dioxide concentration of the product gas, the ozone concentration of the product gas, the nitric oxide concentration of an inhaled gas, the nitrogen dioxide concentration of the inhaled gas, and the pressure in the chamber.

11. The apparatus of claim 10 , wherein the volume and timing of the inspiration event is received from a ventilator.

12. The apparatus of claim 9 , wherein the electrical pulses are in the form of a pulse train including pulse groups having pulses with different pulse widths.

13. The apparatus of claim 9 , wherein the series of electric arcs generates a reduced level of at least one of nitrogen dioxide or ozone.

14. The apparatus of claim 13 , further comprising a scavenger for further reducing the reduced level of nitrogen dioxide, the scavenger comprising one or more of KaOH, CaOH, CaC03, and NaOH.

15. The apparatus of claim 13 , wherein the reduced level of nitrogen dioxide has a concentration that is less than 20% of a concentration of the generated nitric oxide.

16. The apparatus of claim 9 , wherein the series of electric arcs is initiated when the chamber has a pressure greater than 1 ATA.

17. The apparatus of claim 9 , wherein the electrodes comprise at least one of a noble metal, iridium, or nickel.

18. The apparatus of claim 9 , further comprising a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber.

Assignees

• Massachusetts Gen Hospital

Inventors

• Zapol Warren M
• Yu Binglan
• Hardin Paul
• Hickcox Matthew

Classifications

• C01B21/203

  Preparation of nitrogen oxides using a plasma or an electric discharge · CPC title

• B01D2251/404

  of calcium · CPC title

• B01D2251/306

  of potassium · CPC title

• B01D2251/304

  of sodium · CPC title

• B01D53/56

  Nitrogen oxides (B01D53/60 takes precedence) · CPC title