Tissue filler compositions and methods of use

Patent metadata

Field	Value
Publication number	US-10772990-B2
Application number	US-201816226818-A
Country	US
Kind code	B2
Filing date	Dec 20, 2018
Priority date	Apr 1, 2014
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.

First claim

The invention claimed is:

1. A method for promoting wound healing, the method comprising:
administering a composition to a wound area to be treated, wherein the composition comprises a tissue filler medium and a fluorophore; and wherein the composition is non-photopolymerizable; and
illuminating the wound area to be treated with light having a wavelength which can be absorbed by the fluorophore;
wherein the method promotes wound healing in the wound area.

2. The method of claim 1 , wherein the wound area to be treated is soft tissue.

3. The method of claim 1 , wherein the administering of the composition is by injection.

4. The method of claim 1 , wherein the administering of the composition is by implantation.

5. The method of claim 1 , wherein the composition is selected in a form selected from a cohesive gel and a hydrated gel.

6. The method of claim 1 , wherein the tissue filler is a dermal filler.

7. The method of claim 1 , wherein the tissue filler medium comprises a polymer.

8. The method of claim 7 , wherein the polymer is selected from proteins, peptides, polypeptides, polylysine, collagens, pro-collagens, elastins, and laminins.

9. The method of claim 7 , wherein the polymer is selected from poly(vinyl alcohol), polyethylene glycol, polyvinlyl amine, polyallylamine, deacetylated polyacrylamide, polyacrylic acid, and polymethacrylic acid.

10. The method of claim 1 , wherein the tissue filler medium comprises cross-linked hyaluronic acid.

11. The method of claim 10 , wherein the cross-linked hyaluronic acid is in particulate form.

12. The method of claim 1 , wherein the composition further comprises light reflecting particles.

13. The method of claim 1 , wherein the composition further comprises an injectable medium supporting the particles.

14. The method of claim 13 , wherein the injectable medium comprises hyaluronic acid which is relatively less cross-linked than the hyaluronic acid in particulate form.

15. The method of claim 1 , wherein the composition is transparent or translucent.

16. The method of claim 1 , wherein the tissue filler medium retains the fluorophore within the composition during administering of the composition, and at least during a portion of the illumination.

17. The method of claim 1 , wherein the tissue filler medium is biodegradable.

18. The method of claim 1 , wherein the fluorophore can be activated by light having a wavelength in the visible range.

19. The method of claim 1 , wherein the fluorophore is not in a liposomal form in the composition.

20. The method of claim 1 , wherein the wound is an amputation, a burn, an incision, an excision, a lesion, a laceration, an abrasion, a puncture wound, a penetrating wound, a surgical wound, a contusion, a hematoma, a crushing injury, a pressure ulcer, a venous ulcer, an arterial ulcer, a diabetic ulcer, or a wound caused by periodontitis.

Assignees

• Klox Tech Inc

Inventors

• Nikolis Andreas
• Herbert Lise

Classifications

• A61L27/14

  Macromolecular materials · CPC title

• A61K8/735

  Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof · CPC title

• A61K8/498

  having 6-membered rings or their condensed derivatives, e.g. coumarin · CPC title

• A61L27/52 Primary

  Hydrogels or hydrocolloids · CPC title

• A61L2300/442

  Colorants, dyes · CPC title