Use of a bacterium isolated from the genus Pseudoalteromonas, cyclolipopeptides and uses thereof

Patent metadata

Field	Value
Publication number	US-10772930-B2
Application number	US-201815937416-A
Country	US
Kind code	B2
Filing date	Mar 27, 2018
Priority date	May 24, 2013
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.

First claim

We claim:

1. An anti-bacterial composition comprising (a) a therapeutically effective amount of the cyclolipoprotein of formula A:

wherein R is selected from the group consisting of:
(i) alkyl groups comprising between 4 and 20 carbon atoms, except nonyl and undecyl groups;
(ii) alkylene groups comprising between 4 and 20 carbon atoms, except undec-4-ylene and tridec-6-ylene groups;
(iii) alkyl groups substituted with an —OH group and comprising between 4 and 20 carbon atoms; and
(iv) alkylene groups substituted with an —OH group and comprising between 4 and 20 carbon atoms, and (b) an effective amount of an adjuvant.

2. The composition according to claim 1 , wherein R is selected from the group consisting of:
(i) alkyl groups comprising between 6 and 14 carbon atoms, except nonyl and undecyl groups;
(ii) alkylene groups comprising between 6 and 14 carbon atoms, except undec-4-ylene and tridec-6-ylene groups;
(iii) alkyl groups substituted with an —OH group and comprising between 6 and 14 carbon atoms; and
(iv) alkylene groups substituted with an —OH group and comprising between 6 and 14 carbon atoms.

3. The composition according to claim 2 , wherein R is selected from the group consisting of the groups: nonylene, nonanol, heptyl, octylene, octyl, decyldiene, decanyl, decanol, decylene, octenol, dodecylene and tridecyltriene.

4. The composition according to claim 1 , wherein the cyclolipoprotein is obtained from a bacterium.

5. The composition according to claim 1 , wherein the composition is a pharmaceutical composition.

6. The composition according to claim 3 , wherein R is nonyl-2-ene.

7. The composition according to claim 3 , wherein R is nonan-2-ol.

8. The composition according to claim 1 , further comprising an organic solvent.

9. The composition according to claim 8 , wherein the organic solvent is glycerol or a glycol, or a mixture of glycerol and the glycol.

Assignees

• Centre Nat Rech Scient
• Univ Rennes
• Univ Bretagne Occidentale

Inventors

• Desriac Florie
• Fleury Yannick
• Le Chevalier Patrick
• Destoumieux Delphine
• Simon Matthieu

Classifications

• C12R2001/01

  Bacteria or Actinomycetales {; using bacteria or Actinomycetales} · CPC title

• C12N1/205

  Bacterial isolates · CPC title

• Y02A40/818

  Alternative feeds for fish, e.g. in aquacultures · CPC title

• C07K7/56

  the cyclisation not occurring through 2,4-diamino-butanoic acid · CPC title

• A23K10/18

  of live microorganisms · CPC title