Liquid nutritional composition containing 5-methyltetrahydrofolic acid

Patent metadata

Field	Value
Publication number	US-10772889-B2
Application number	US-201616061522-A
Country	US
Kind code	B2
Filing date	Dec 19, 2016
Priority date	Dec 21, 2015
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

A liquid nutritional composition including 5-methyltetrahydrofolic acid (5-MTHF) is provided. The liquid nutritional composition also includes ascorbic acid and a protein system containing methionine to inhibit or reduce oxidation of the 5-MTHF and provide an active folate level of the liquid nutritional composition that remains stable over the shelf life of the liquid nutritional composition.

First claim

What is claimed is:

1. A liquid nutritional composition comprising:
a protein system comprising methionine;
5-methyltetrahydrofolic acid or a salt thereof; and
ascorbic acid or a salt thereof;
wherein a molar ratio of the methionine to the 5-methyltetrahydrofolic acid is from 3,000:1 to 5,200:1.

2. The liquid nutritional composition according to claim 1 , wherein a molar ratio of the ascorbic acid to the 5-methyltetrahydrofolic acid is from 1,800:1 to 30,000:1.

3. The liquid nutritional composition according to claim 1 , wherein the protein system comprises a milk protein and a soy protein, and wherein a weight ratio of the milk protein to the soy protein is from 80:20 to 50:50.

4. The liquid nutritional composition according to claim 1 , wherein a weight ratio of the protein system to the 5-methyltetrahydrofolic acid is from 50,000:1 to 75,000:1.

5. The liquid nutritional composition according to claim 1 , wherein the protein system comprises soluble protein, and wherein a weight ratio of the soluble protein to the 5-methyltetrahydrofolic acid is from 22,000:1 to 50,000:1.

6. The liquid nutritional composition according to claim 1 , wherein the liquid nutritional composition comprises the calcium salt of 5-methyltetrahydrofolic acid.

7. The liquid nutritional composition according to claim 1 , wherein the liquid nutritional composition comprises the sodium salt of ascorbic acid.

8. The liquid nutritional composition according to claim 1 , further comprising a carbohydrate and a fat.

9. The liquid nutritional composition according to claim 8 , wherein the carbohydrate comprises at least one of sucrose, lactose, fructose, glucose, corn syrup, maltodextrin, fructooligosaccharides, galactooligosaccharides, cornstarch, polydextrose, starch, and a sugar alcohol.

10. The liquid nutritional composition according to claim 8 , wherein the fat comprises at least one of canola oil, corn oil, coconut oil, fractionated coconut oil, soy oil, high oleic soy oil, olive oil, safflower oil, high oleic safflower oil, high gamma-linolenic acid safflower oil, medium chain triglyceride oil, sunflower oil, high oleic sunflower oil, palm oil, palm kernel oil, palm olein, high oleic canola oil, marine oil, cottonseed oil, eicosapentaenoic acid, docosahexaenoic acid, gamma-linolenic acid, rice bran oil, wheat germ oil, algal oil, nut oil, fungal oil, and conjugated linolenic acid.

11. A liquid nutritional composition comprising:
a protein system comprising from 1.75% to 2.55% methionine by weight of the protein system;
5-methyltetrahydrofolic acid or a salt thereof; and
ascorbic acid or a salt thereof;
wherein a molar ratio of the methionine to the 5-methyltetrahydrofolic acid is from 3,000:1 to 5,200:1.

12. The liquid nutritional composition according to claim 11 , wherein a molar ratio of the ascorbic acid to the 5-methyltetrahydrofolic acid is from 1,800:1 to 30,000:1.

13. The liquid nutritional composition according to claim 11 , wherein the protein system comprises a milk protein.

14. The liquid nutritional composition according to claim 13 , wherein the protein system further comprises a soy protein, and wherein a weight ratio of the milk protein to the soy protein is from 80:20 to 50:50.

15. The liquid nutritional composition according to claim 11 , wherein a weight ratio of the protein system to the 5-methyltetrahydrofolic acid is from 50,000:1 to 75,000:1.

16. The liquid nutritional composition according to claim 11 , wherein the liquid nutritional composition comprises the calcium salt of 5-methyltetrahydrofolic acid.

17. The liquid nutritional composition according to claim 11 , wherein the liquid nutritional composition comprises the sodium salt of ascorbic acid.

18. The liquid nutritional composition according to claim 11 , further comprising a carbohydrate and a fat.

19. The liquid nutritional composition according to claim 18 , wherein the carbohydrate comprises at least one of sucrose, lactose, fructose, glucose, corn syrup, maltodextrin, fructooligosaccharides, galactooligosaccharides, cornstarch, starch, polydextrose, and a sugar alcohol.

20. The liquid nutritional composition according to claim 18 , wherein the fat comprises at least one of canola oil, corn oil, coconut oil, fractionated coconut oil, soy oil, high oleic soy oil, olive oil, safflower oil, high oleic safflower oil, high gamma-linolenic acid safflower oil, medium chain triglyceride oil, sunflower oil, high oleic sunflower oil, palm oil, palm kernel oil, palm olein, high oleic canola oil, marine oil, cottonseed oil, eicosapentaenoic acid, docosahexaenoic acid, gamma-linolenic acid, rice bran oil, wheat germ oil, algal oil, nut oil, fungal oil, and conjugated linolenic acid.

Assignees

• Abbott Lab

Inventors

• Johns Paul
• Baxter Jeffrey
• Terp Megan
• Dewille Normanella
• Heo Youngsuk

Classifications

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A61K31/519 Primary

  ortho- or peri-condensed with heterocyclic rings · CPC title

• A23L33/16

  Inorganic salts, minerals or trace elements · CPC title

• A23L33/115

  Fatty acids or derivatives thereof; Fats or oils · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title