Apparatus, systems and methods for intraoperative imaging

Patent metadata

Field	Value
Publication number	US-10772504-B2
Application number	US-201715687205-A
Country	US
Kind code	B2
Filing date	Aug 25, 2017
Priority date	Sep 20, 2013
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.

First claim

What is claimed is:

1. A system for identifying and removing biological material, comprising:
an imager comprising an imaging surface;
a visualization system in electrical communication with the imager wherein;
the imager has an overall thickness of less than 1 mm, and
the visualization system is configured to visualize an optical tag that is an up converting nanoparticle conjugated to a protein.

2. The system of claim 1 , further comprising an optical filter.

3. The system of claim 2 , wherein the optical filter is an angle-insensitive filter.

4. The system of claim 1 , wherein the imaging surface is operationally integrated with a surgical tool.

5. The system of claim 1 , wherein the imager is flexible.

6. The system of claim 1 , wherein the imaging surface comprises a plurality of individual pixels.

7. The system of claim 1 , wherein the imager has an overall thickness of less than 0.5 mm.

8. The system of claim 1 , wherein the imager has an overall thickness of less than 0.3 mm.

9. The system of claim 1 , wherein the imager has an overall thickness of less than 0.1 mm.

10. The system of claim 1 , wherein the imager has an overall thickness of less than 100 μm.

11. The system of claim 1 , further comprising a broad-emission LED light source.

12. The system of claim 1 , wherein the imager is configured to function without the need for an optical waveguide or an optical filter.

13. The system of claim 1 , wherein the imager is constructed and arranged to directly illuminate a tissue surface.

14. The system of claim 1 , wherein the imaging surface comprises a plurality of individual pixels with nano-grids for angle selective imaging.

15. The system of claim 1 , wherein the tissue surface is illuminated directly through the imager and up converting optical tags re-emitted at a shorter wavelength which is detected by the imager.

16. The system of claim 1 , wherein the system is constructed and arranged for time-gated imaging.

17. The system of claim 1 , wherein the imager has an overall thickness of less than 50 μm.

Assignees

• Univ California

Inventors

• Anwar Moshiur M
• Park Catherine
• Boser Bernard

Classifications

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/4381

  Prostate evaluation or disorder diagnosis · CPC title

• A61B5/0091

  for mammography · CPC title

• A61K49/0067

  quantum dots, fluorescent nanocrystals · CPC title

• A61K49/0058

  Antibodies · CPC title