Refined chlorogenic acid-containing composition

Patent metadata

Field	Value
Publication number	US-10772340-B2
Application number	US-201716345118-A
Country	US
Kind code	B2
Filing date	Sep 28, 2017
Priority date	Oct 26, 2016
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

Provided is a purified chlorogenic acid-containing composition, having: a content of a chlorogenic acid in solids of from 10 mass % to 70 mass %; a “glucose/chlorogenic acid” mass ratio of from 0.1 to 0.9; a “caffeine/chlorogenic acid” mass ratio of 0.05 or less; and a pH of from 1 to 5.

First claim

The invention claimed is:

1. A purified chlorogenic acid-containing composition, having:
a content of a chlorogenic acid in solids of from 10 mass % to 70 mass %;
a mass ratio of glucose/chlorogenic acid of from 0.1 to 0.9;
a mass ratio of caffeine/chlorogenic acid of 0.05 or less; and
a pH of from 1 to 5.

2. The purified chlorogenic acid-containing composition according to claim 1 , wherein the purified chlorogenic acid-containing composition further has a mass ratio of acetic acid/malic acid of from 0 to 0.3.

3. The purified chlorogenic acid-containing composition according to claim 1 , wherein a content of a lipid in solids is from 0 mass % to 0.3 mass %.

4. The purified chlorogenic acid-containing composition according to claim 1 , wherein the content of the chlorogenic acid in solids is from 20 mass % to 60 mass %.

5. The purified chlorogenic acid-containing composition according to claim 1 , wherein the mass ratio of glucose/chlorogenic acid is from 0.12 to 0.45.

6. The purified chlorogenic acid-containing composition according to claim 1 , wherein a content of glucose in solids is from 4.5 mass % to 30 mass %.

7. The purified chlorogenic acid-containing composition according to claim 1 , wherein a content of caffeine in solids is 0.2 mass % or less.

8. The purified chlorogenic acid-containing composition according to claim 1 , wherein a content of acetic acid in solids is 0.08 mass % or less.

9. The purified chlorogenic acid-containing composition according to claim 1 , wherein the pH is from 2.5 to 4.5.

10. A method of producing a purified chlorogenic acid-containing composition, comprising:
a first step of bringing a chlorogenic acid-containing composition into contact with at least one of adsorbent selected from the group consisting of activated carbon, acid clay, and activated clay; and
a second step of subjecting the chlorogenic acid-containing composition after the contact with the adsorbent to at least one selected from the group consisting of the following steps (A) and (B) under an acidic condition:
(A) a step of concentrating the chlorogenic acid-containing composition by 6 times or more at a temperature of from 20° C. to 70° C.; and
(B) a step of adding glucose to the chlorogenic acid-containing composition.

11. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein the acidic condition comprises a pH of from 1 to 5.

12. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein the chlorogenic acid-containing composition comprises an extract of coffee beans.

13. The method of producing a purified chlorogenic acid-containing composition according to claim 12 , wherein the coffee beans comprise at least one selected from the group consisting of green coffee beans, decaffeinated green coffee beans, roasted coffee beans having an L value of 45 or more, and decaffeinated roasted coffee beans having an L value of 25 or more.

14. The method of producing a purified chlorogenic acid-containing composition according to claim 12 , wherein the coffee beans comprise at least one selected from the group consisting of unground coffee beans and ground coffee beans having an average particle size of from 0.3 mm to 7.5 mm.

15. The method of producing a purified chlorogenic acid-containing composition according to claim 12 , wherein an extraction method for the extract of coffee beans comprises column extraction.

16. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein the chlorogenic acid-containing composition to be used in the first step has a concentration of solids of 4.7 mass % or less.

17. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein the chlorogenic acid-containing composition to be used in the first step has a content of a chlorogenic acid in solids of from 1 mass % to 70 mass %.

18. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein the second step comprises subjecting the chlorogenic acid-containing composition to both the step (A) and the step (B).

19. The method of producing a purified chlorogenic acid-containing composition according to claim 10 , wherein a concentration method in the step (A) comprises a normal-pressure concentration method or a reduced-pressure concentration method.

20. A method of producing a purified chlorogenic acid-containing composition, comprising:
a first step of bringing a chlorogenic acid-containing composition into contact with at least one of adsorbent selected from the group consisting of activated carbon, acid clay, and activated clay; and
a second step of subjecting the chlorogenic acid-containing composition after the contact with the adsorbent to at least one selected from the group consisting of the following steps (A) and (B) under an acidic condition of a pH of from 1 to 5:
(A) a step of concentrating the chlorogenic acid-containing composition by 6 times or more at a temperature of from 20° C. to 70° C. by using a normal-pressure concentration method or a reduced-pressure concentration method; and
(B) a step of adding glucose to the chlorogenic acid-containing composition, to adjust a mass ratio of glucose/chlorogenic acid to from 0.12 to 0.45.

Assignees

• Kao Corp

Inventors

• Hotta Yusuke
• Sugiyama Yukiteru

Classifications

• A61K36/742

  Coffea, e.g. coffee · CPC title

• A23L33/105 Primary

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P17/18

  Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) · CPC title

• A61P9/12

  Antihypertensives · CPC title