Electrolyte concentration measurement device

Patent metadata

Field	Value
Publication number	US-10768136-B2
Application number	US-201716319839-A
Country	US
Kind code	B2
Filing date	Jun 13, 2017
Priority date	Jul 26, 2016
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

An electrolyte concentration measurement device includes a measurement unit that includes an ion selective electrode, a reference electrode and a potential measurement unit; a record and calculation unit that obtains an ion concentration of an internal standard liquid or a specimen; and a concentration value correction/determination unit that determines whether the ion concentration of the internal standard liquid is within a preset value range, and corrects an ion concentration value of the internal standard liquid obtained by the record and calculation unit, in which the measurement unit includes an internal standard liquid bottle storage unit storing a plurality of bottles, and the concentration value correction/determination unit corrects the obtained ion concentration of the internal standard liquid after the bottle is switched, by using information of the ion concentration before the bottle accommodating the internal standard liquid is switched.

First claim

The invention claimed is:

1. An electrolyte concentration measurement device, comprising:
a measurement unit that includes an ion selective electrode, a reference electrode, and a potential measurement unit, and the measurement unit measuring, by the potential measurement unit, a potential difference when an internal standard liquid or specimen is supplied to the ion selective electrode;
a reagent supply unit that supplies a reagent containing the internal standard liquid to the measurement unit;
a record and calculation processor configured to process information of the potential difference measured by the measurement unit and obtains an ion concentration of the internal standard liquid or the specimen;
a concentration value correction/determination processor configured to determine whether the ion concentration of the internal standard liquid, which is obtained by the record and calculation unit, is within a preset value range, and corrects the ion concentration value of the internal standard liquid obtained by the record and calculation unit;
an output device configured to output a result determined by the concentration value correction/determination unit; and
a controller that controls the measurement unit, the record and calculation processor, the concentration value correction/determination processor, and the output device, wherein
the reagent supply unit includes a bottle storage unit that stores a plurality of bottles, each accommodating a reagent such as the internal standard liquid, for each type of reagent, and a bottle switching unit that detects a remaining amount of the reagent in each of the plurality of bottles stored in the bottle storage unit, switches a bottle in which the remaining amount of the reagent is smaller than a preset amount due to supplying the reagent to the measurement unit, to a bottle in which the remaining amount of the reagent is sufficiently larger than the preset amount, by a bottle that is stored in the bottle storage unit and accommodates the same type of reagent, and supplies the reagent to the measurement unit, and
the concentration value correction/determination processor corrects the ion concentration of the internal standard liquid or the specimen obtained by the record and calculation processor after the bottle accommodating the same type of reagent is switched, by using information of the ion concentration of the internal standard liquid or the specimen obtained by the record and calculation processor before the bottle is switched, when a bottle supplying a reagent to the measurement unit is switched among a plurality of bottles accommodating the same type of reagent in the reagent supply unit, and
the bottle switching unit in the reagent supply unit a remaining amount of the reagent in each of the plurality of bottles, and a flow path switching unit that switches a flow path of the reagent supplying the reagent to the measurement unit among the plurality of bottles accommodating the same type of reagent based on information of the remaining amount of the reagent in the bottle detected.

2. The electrolyte concentration measurement device according to claim 1 , further comprising:
an alarm that is issued if a reagent bottle to be replaced is not replaced with a new reagent bottle.

3. The electrolyte concentration measurement device according to claim 1 , wherein
a drug substance corresponding to the reagent accommodated in the bottle is supplied by the bottle storage unit, and the electrolyte concentration measurement device further comprises a pure water supply unit that supplies pure water to the bottle, and a stirring mechanism that stirs and mixes the drug substance and the pure water in the bottle in which the drug substance is supplied from the drug substance supply unit and the pure water is supplied from the pure water supply unit.

4. An electrolyte concentration measurement device, comprising:
a measurement unit that includes an ion selective electrode, a reference electrode, and a potential measurement unit, and the measurement unit measuring, by the potential measurement unit, a potential difference when an internal standard liquid or specimen is supplied to the ion selective electrode;
a reagent supply unit that supplies a reagent containing the internal standard liquid to the measurement unit;
a record and calculation processor configured to process information of the potential difference measured by the measurement unit and obtains an ion concentration of the internal standard liquid or the specimen;
a concentration value correction/determination processor configured to determine whether the ion concentration of the internal standard liquid, which is obtained by the record and calculation unit, is within a preset value range, and corrects the ion concentration value of the internal standard liquid obtained by the record and calculation unit;
an output device configured to output a result determined by the concentration value correction/determination unit; and
a controller that controls the measurement unit, the record and calculation processor, the concentration value correction/determination processor, and the output device, wherein
the reagent supply unit includes a bottle storage unit that stores a plurality of bottles, each accommodating a reagent such as the internal standard liquid, for each type of reagent, and a bottle switching unit that detects a remaining amount of the reagent in each of the plurality of bottles stored in the bottle storage unit, switches a bottle in which the remaining amount of the reagent is smaller than a preset amount due to supplying the reagent to the measurement unit, to a bottle in which the remaining amount of the reagent is sufficiently larger than the preset amount, by a bottle that is stored in the bottle storage unit and accommodates the same type of reagent, and supplies the reagent to the measurement unit, and
the concentration value correction/determination processor corrects the ion concentration of the internal standard liquid or the specimen obtained by the record and calculation processor after the bottle accommodating the same type of reagent is switched, by using information of the ion concentration of the internal standard liquid or the specimen obtained by the record and calculation processor before the bottle is switched, when a bottle supplying a reagent to the measurement unit is switched among a plurality of bottles accommodating the same type of reagent in the reagent supply unit,
a reagent bottle replacement mechanism by which a device operator can replace the other reagent bottle with a new reagent bottle while an electrolyte concentration measurement is implemented by using a reagent in one reagent bottle.

5. An electrolyte concentration measurement device, comprising:
a measurement unit that includes an ion selective electrode, a reference electrode, and a potential measurement unit, and the measurement unit measuring, by the potential measurement unit, a potential difference when an internal standard liquid or specimen is supplied to the ion selective electrode;
a reagent supply unit that supplies a reagent containing the internal standard liquid to the measurement unit;
a record and calculation processor configured to process information of the potential difference measured by the measurement unit and obtains an ion concentration of the internal standard liquid or the specimen;
a concentration value correction/determination processor configured to determine whether the ion concentration of the internal standard liquid, which is obtained by the record and calculation unit, is within a preset value range, and corrects the ion concentration value of the internal standard liquid obtained by the record and calculation unit;
an output device configured to output a result determined by

Assignees

• Hitachi High Tech Corp

Inventors

• Kishioka Atsushi
• Ono Tetsuyoshi

Classifications

• G01N33/493

  urine · CPC title

• G01N33/487

  of liquid biological material · CPC title

• G01N33/492

  Determining multiple analytes · CPC title

• G01N27/4163 Primary

  checking the operation of, or calibrating, the measuring apparatus (G01N27/3274, G01N27/4175 and G01N33/0006 take precedence) · CPC title

• G01N1/00

  Sampling; Preparing specimens for investigation · CPC title