Method of producing tissue regeneration substrate

Patent metadata

Field	Value
Publication number	US-10765780-B2
Application number	US-201515524922-A
Country	US
Kind code	B2
Filing date	Dec 3, 2015
Priority date	Dec 5, 2014
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

The present invention aims to provide a tissue regeneration substrate excellent in penetrability to cells as well as capable of effectively preventing cell leakage from the tissue regeneration substrate to accelerate tissue regeneration; and a method of producing the tissue regeneration substrate. The present invention relates to a tissue regeneration substrate including: a nonwoven fabric made of a bioabsorbable material, the tissue regeneration substrate having a laminated structure in which a layer containing a nonwoven fabric having an average pore size of 20 to 50 μm and a layer containing a nonwoven fabric having an average pore size of 5 to 20 μm are integrated.

First claim

The invention claimed is:

1. A method of producing a tissue regeneration substrate comprising:
preparing a layer containing a nonwoven fabric having an average pore size of 20 to 50 μm;
discharging threads made of a bioabsorbable material on the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm by melt blowing to form a layer containing a nonwoven fabric having an average pore size of 5 to 18 μm to produce a stack; and
needle-punching the stack to integrate the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm and the layer containing a nonwoven fabric having an average pore size of 5 to 18 μm.

2. A method of producing a tissue regeneration substrate comprising:
preparing a layer containing a nonwoven fabric having an average pore size of 20 to 50 μm;
preparing a layer containing a nonwoven fabric having an average pore size of 5 to 18 μm;
stacking the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm and the layer containing a nonwoven fabric having an average pore size of 5 to 18 μm to produce a stack; and
needle-punching the stack to integrate the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm and the layer containing a nonwoven fabric having an average pore size of 5 to 18 μm.

3. The method of producing the tissue regeneration substrate according to claim 1 , further comprising, after preparing the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm, fluffing a surface of the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm on which the layer containing a nonwoven fabric having an average pore size of 5 to 18 μm is to be stacked.

4. The method of producing the tissue regeneration substrate according to claim 2 , further comprising, after preparing the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm, fluffing a surface of the layer containing a nonwoven fabric having an average pore size of 20 to 50 μm on which the layer containing a nonwoven fabric having an average pore size of 5 to 18 μm is to be stacked.

Assignees

• Gunze Kk

Inventors

• Arimura Hidetoshi
• Ide Keita

Classifications

• B32B2250/20

  All layers being fibrous or filamentary · CPC title

• A61L27/58 Primary

  Materials at least partially resorbable by the body · CPC title

• A61F2/28

  Bones · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• A61L27/56 Primary

  Porous materials, {e.g. foams or sponges} · CPC title