Use of low dose IL-2 for treating autoimmune—related or inflammatory disorders

Patent metadata

Field	Value
Publication number	US-10765723-B2
Application number	US-201916361902-A
Country	US
Kind code	B2
Filing date	Mar 22, 2019
Priority date	Mar 11, 2011
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.

First claim

The invention claimed is:

1. A method for treating systemic vasculitis, the method comprises administering to a human subject in need thereof an effective amount of repeated doses of interleukin-2 (IL-2), wherein each dose of the IL-2 is between 0.1 MIU/day and 3.5 MIU/day.

2. The method of claim 1 , wherein the subject is administered IL-2 at a dose of 1 MIU/day to 3.5 MIU/day.

3. The method of claim 1 , wherein the subject is administered IL-2 at a dose of 1.5 MIU/day to 3.5 MIU/day.

4. The method of claim 1 , wherein the subject is administered IL-2 at a dose of 0.5 MIU/day to 1.5 MIU/day.

5. The method of claim 1 , wherein the subject is administered IL-2 at a dose of 1.5 MIU/day.

6. The method of claim 1 , wherein the subject is administered des-alanyl-1, serine-125 human interleukin-2.

7. The method of claim 1 , wherein the IL-2 is administered once per day during at least 3 consecutive days.

8. The method of claim 1 , wherein the IL-2 is administered to the subject in a first course of treatment once per day during 3 to 7 days, followed by a maintenance dose given to the subject once a week, once a month, or twice a month.

9. The method of claim 8 , wherein the maintenance dose is administered one to four weeks after the last dose of the first course of treatment.

10. The method of claim 1 , wherein the IL-2 is administered by a subcutaneous route.

Assignees

• Inst Nat Sante Rech Med
• Assist Publique—Hopitaux De Paris
• Univ Sorbonne

Inventors

• Klatzmann David
• Saadoun David
• Cacoub Patrice
• Rosenzwajg Michèle
• Piaggio Eliane
• Bensimon Gilbert
• Bernard Claude

Classifications

• A61P37/02

  Immunomodulators · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title