Oral composition

Patent metadata

Field	Value
Publication number	US-10765609-B2
Application number	US-201716305643-A
Country	US
Kind code	B2
Filing date	May 29, 2017
Priority date	May 31, 2016
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

The present invention is directed to an oral composition having an improved ability to incorporate fluoride ions into tooth enamel and an enhanced remineralization effect.

First claim

What is claimed is:

1. An oral composition comprising the following ingredients (A), (B), (C), and (D):
(A) 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride;
(B) 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol;
(C) 0.1 mass % or more and 10 mass % or less of a surfactant comprising one or more selected from the group consisting of (c1) a nonionic surfactant selected from the group consisting of sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester and (c2) an anionic surfactant being fatty acid having 12 or more and 22 or less carbon atoms or a salt thereof; and
(D) water,

wherein the content of the ingredient (c1) is 0.05 mass % or more; a mass ratio of the content of the ingredient (A) in terms of fluorine atoms to the content of the ingredient (B), (A)/(B), is 0.001 or more and 0.2 or less; and the molar amount of (E) a polyvalent metal compound other than the ingredient (A) is less than 0.1-fold the molar amount of the ingredient (A).

2. The oral composition according to claim 1 , wherein
when the ingredient (C) does not contain the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less; and
when the ingredient (C) contains both the ingredient (c1) and the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less; and a mass ratio of the content of the ingredient (B) to the content of the ingredient (c2), (B)/(c2), is 2 or more and 180 or less.

3. The oral composition according to claim 1 , wherein a mass ratio of the content of the ingredient (b1) to the content of the ingredient (b2), ((b1)/(b2)), is 0.5 or more and 5 or less.

4. The oral composition according to claim 1 , wherein a mass ratio of the sum of the content of the ingredient (b1) and the content of the ingredient (b2) to the content of the ingredient (B), (((b1)+(b2))/(B)), is 0.85 or more and 1 or less.

5. The oral composition according to claim 1 , wherein the content of a cellulose binder is 0.3 mass % or less.

6. The oral composition according to claim 5 , wherein the cellulose binder is one or two selected from the group consisting of sodium carboxymethyl cellulose and hydroxyalkyl cellulose.

7. The oral composition according to claim 1 , wherein the content of a water-absorbing ingredient being solid at 20° C. and selected from the group consisting of abrasive silica, sorbitol, and xylitol is 30 mass % or less.

8. The oral composition according to claim 1 , wherein a mass ratio of the content of the ingredient (B) to the sum of the content of the ingredient (c1) and the content of the ingredient (c2) in terms of fatty acids, (B)/((c1)+(c2)), is higher than 1 and 40 or less.

9. The oral composition according to claim 1 , wherein a mass ratio of the content of (F) oil other than the ingredient (B), the ingredient (C), an oil-soluble medicinal ingredient, and a flavoring agent to the content of the ingredient (B), (F)/(B), is less than 1.

10. The oral composition according to claim 1 , wherein the content of the ingredient (D) is 50 mass % or more and 95 mass % or less.

11. The oral composition according to claim 1 , wherein the content of polyoxyethylene hydrogenated castor oil is 0.5 mass % or less.

12. The oral composition according to claim 1 , wherein the composition is an agent for promoting incorporation of fluoride ions into teeth.

13. A method of producing the oral composition according to claim 1 , comprising:
a step (I) of mixing a mixture liquid comprising the ingredient (B) and the ingredient (C) at a temperature not lower than the melting point of the ingredient (B) and not higher than 90° C.; and
a step (II) of adding thereto the ingredient (A).

14. A method for incorporating fluoride ions into teeth by applying the composition according to claim 1 into the oral cavity.

15. An oral composition comprising the following ingredients (A), (B), (C), and (D):
(A) 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride;
(B) 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol;
(C) 0.1 mass % or more and 10 mass % or less of a surfactant comprising one or more selected from the group consisting of (c1) a nonionic surfactant selected from the group consisting of sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester and (c2) an anionic surfactant being fatty acid having 12 or more and 22 or less carbon atoms or a salt thereof; and
(D) water,
wherein:
the content of the ingredient (c1) is 0.05 mass % or more;
a mass ratio of the content of the ingredient (A) in terms of fluorine atoms to the content of the ingredient (B), (A)/(B), is 0.001 or more and 0.2 or less;
the molar amount of (E) a polyvalent metal compound other than the ingredient (A) is less than 0.1-fold the molar amount of the ingredient (A);
wherein,
when the ingredient (C) does not contain the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less;
when the ingredient (C) contains both the ingredient (c1) and the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less and a mass ratio of the content of the ingredient (B) to the content of the ingredient (c2), (B)/(c2), is 2 or more and 180 or less.

16. The oral composition of claim 1 , wherein the content of the ingredient (c1) is 0.05 mass % or more and 10 mass % or less.

17. The oral composition of claim 15 , wherein the content of the ingredient (c1) is 0.05 mass % or more and 10 mass % or less.

Assignees

• Kao Corp

Inventors

• Takahashi Noritaka
• Nagata Ryosuke
• Asada Takuya

Classifications

• A61K8/4993

  Derivatives containing from 2 to 10 oxyalkylene groups · CPC title

• A61K8/4973

  with oxygen as the only hetero atom · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title

• A61K8/342

  Alcohols having more than seven atoms in an unbroken chain · CPC title

• A61K8/24

  Phosphorous; Compounds thereof · CPC title