Antibody substituting for function of blood coagulation factor viii
US-2019359728-A1 · Nov 28, 2019 · US
Multispecific antigen-binding molecules having blood coagulation factor VIII (FVIII) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ingredient
US10759870B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10759870-B2 |
| Application number | US-201816099341-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 27, 2018 |
| Priority date | Sep 29, 2017 |
| Publication date | Sep 1, 2020 |
| Grant date | Sep 1, 2020 |
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Abstract
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Bispecific antibodies whose FIX activation-inhibiting activity is not elevated and whose FVIII cofactor function-substituting activity is elevated have been successfully discovered.
First claim
Opening claim text (preview).
The invention claimed is: 1. A bispecific antibody comprising a first antibody heavy chain and a first antibody light chain that bind to blood coagulation factor IX and/or activated blood coagulation factor IX, and a second antibody heavy chain and a second antibody light chain which bind to blood coagulation factor X, wherein the bispecific antibody is any of (a) to (t) below: (a) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 56, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 61, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 73, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 84; (b) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 57, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 62, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 73, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 84; (c) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 58, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 63, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 74, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 85; (d) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 58, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 64, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 74, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 85; (e) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 57, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 62, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 75, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 86; (f) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 57, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 62, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 76, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 87; (g) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 57, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 62, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 74, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 85; (h) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 65, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 74, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 85; (i) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 66, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 74, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 85; (j) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 66, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 77, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 88; (k) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 67, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 77, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 88; (l) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 67, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 78, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 89; (m) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 68, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 77, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 88; (n) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 68, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 78, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 89; (o) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 60, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 69, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 79, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 90; (p) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 59, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 70, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 80, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 91; (q) a bispecific antibody which comprises a first antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 60, a first antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 71, a second antibody heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 79, and a second antibody light chain variable region comprising the amino acid sequence of SEQ ID NO: 90; (r) a bispecific antibody which comprises a first antibody heavy chain variable region com
Assignees
Inventors
Classifications
- A61K39/395Primary
Antibodies (agglutinins A61K38/36 {; as drug carriers A61K47/50}); Immunoglobulins; Immune serum, e.g. antilymphocytic serum · CPC title
- C07K16/36Primary
against blood coagulation factors · CPC title
comprising antibodies · CPC title
Constant or Fc region; Isotype · CPC title
variable (Fv) region, i.e. VH and/or VL · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10759870B2 cover?
- Bispecific antibodies whose FIX activation-inhibiting activity is not elevated and whose FVIII cofactor function-substituting activity is elevated have been successfully discovered.
- Who is the assignee on this patent?
- Chugai Pharmaceutical Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K39/395. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).