Devices for trapping and controlling microparticles with radiation

Patent metadata

Field	Value
Publication number	US-10758904-B2
Application number	US-201715625400-A
Country	US
Kind code	B2
Filing date	Jun 16, 2017
Priority date	Feb 5, 2015
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

A particle manipulation device includes a substrate and a microchannel included in the substrate and configured to receive a fluid including particles therein. A biasing structure is formed on the substrate adjacent to, but outside the microchannel. The biasing structure is configured to dispense radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel.

First claim

What is claimed is:

1. A particle manipulation device, comprising:
a chip including:
an electromagnetic radiation generator formed on a substrate of the chip and configured as at least one biasing structure, the at least one biasing structure configured to generate a radio frequency selected to bias movement of the particles within a fluid; and

a control module including:
a generation circuit configured to generate a signal for exciting the at least one biasing structure in response to a feedback loop.

2. The device as recited in claim 1 , further comprising a microchannel including one or more of: a plurality of paths configured to separate particles biased by the biasing structures;
at least one chamber for trapping particles biased by the biasing structures; or at least one chamber for detecting particles.

3. The device as recited in claim 1 , wherein the control module and the chip are integrated on the substrate.

4. The device as recited in claim 1 , wherein the control module and the chip are integrated together on a monolithic substrate.

5. The device as recited in claim 1 , wherein the chip includes electrical contacts and the control module connects to the electrical contacts as an external device.

6. The device as recited in claim 2 , wherein the chip includes a detection structure integrated on the substrate and control module includes a detector interface for providing feedback to adjust the at least one biasing structure.

7. The device as recited in claim 6 , wherein the detection structure includes at least one of an antenna or an image sensor configured to detect characteristics of particles in the microchannel.

8. The device as recited in claim 1 , wherein the at least one biasing structure is configured to generate non-ionizing radiation to apply dielectrophoresis forces to the particles.

9. A method for particle manipulation, comprising:
biasing the particles traveling in a fluid using an electromagnetic radiation generator formed on a substrate and configured as at least one biasing structure, the at least one biasing structure being configured to generate a radio frequency selected to bias movement of the particles within the fluid; and
adjusting the biasing in response to feedback.

10. The method as recited in claim 9 , further comprising introducing particles into a microchannel including one or more paths and chamber configured to trap, separate or redirect the particles responsive to the biasing by the biasing structures.

11. The method as recited in claim 9 , further comprising detecting particles using a sensor configured to detect characteristics of the particles.

12. The method as recited in claim 9 , wherein the substrate includes a microchannel formed thereon, wherein the microchannel is separable from the substrate, and the method further comprising disposing of the microchannel after use.

13. The method as recited in claim 9 , wherein the at least one biasing structure includes at least one antenna, the method further comprising generating radiation to apply dielectrophoresis forces to the particles.

14. The method as recited in claim 9 , wherein the at least one biasing structure generates non-ionizing radiation to apply dielectrophoresis forces to the particles.

Assignees

• IBM

Inventors

• Tirapu Azpiroz Jaione

Classifications

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• B01L3/502761 Primary

  specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules · CPC title

• B03C5/02

  Separators · CPC title

• B01L2300/0877

  Flow chambers · CPC title

• G01N27/44791

  Microapparatus (sample containers with integrated microfluidic structures B01L3/5027) · CPC title