Combination of an oxidant and a photoactivator for the wounds

Patent metadata

Field	Value
Publication number	US-10758744-B2
Application number	US-201916536957-A
Country	US
Kind code	B2
Filing date	Aug 9, 2019
Priority date	Nov 7, 2008
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

There is provided a wound healing composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed.

First claim

The invention claimed is:

1. A method for treating bacterial infection in a wound, comprising:
(a) topically applying on an infected tissue of the wound an effective amount of a composition comprising at least one oxidant, a fluorescent compound, and a healing factor selected from hyaluronic acid, glucosamine and allantoin; and
(b) exposing said composition to actinic light having an emission wavelength between about 400 nm and 600 nm for a time sufficient to cause a change in color of the fluorescent compound.

2. The method according to claim 1 , wherein said composition is exposed to actinic light for a period of about 60 seconds to about 5 minutes.

3. The method according to claim 1 , wherein said composition is exposed to actinic light for a period of about 60 seconds to about 5 minutes per cm 2 of an area to be treated.

4. The method according to claim 1 , wherein the source of actinic light is in continuous motion over an area to be treated.

5. The method according to claim 1 wherein the oxidant is selected from hydrogen peroxide, carhamide peroxide and benzoyl peroxide.

6. The method according to claim 1 , wherein the composition further comprises at least one hydrophilic gelling agent.

7. The method according to claim 6 , wherein the hydrophilic gelling agent is selected from glucose, modified starch, methyl cellulose, carboxymethyl cellulose, propyl hydroxypropyl cellulose, carbomer polymers, alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate, agar, carrageenan, locust bean gum, pectin, and gelatin.

8. The method according to claim 1 , wherein the fluorescent compound is Eosin Y.

9. The method according to claim 1 , wherein the fluorescent compound is selected from a xanthene derivative dye, an azo dye, a biological stain and a carotenoid.

10. The method according to claim 1 , wherein the composition further comprises at least one of rhodamine B, rhodamine WT, rhodamine G, phloxine B, rose bengal, eosin B, fluorescein, erythrosine B, saffranin O, basic fuchsin, acid fuschin, 3,3′ dihexylocarbocyanine iodide, carminic acid, indocyanine green, crocetin, α-crocin (8,8-diapo-8,8-carotenoic acid), zeaxanthine, lycopene, αcarotene, β-carotene, merbromine, bixin, fucoxanthine, methyl violet, neutral red, para red, amaranth, carmoisine, allura red AC, tartrazine, orange G, ponceau 4R, methyl red, murexide-ammonium purpurate, pyronine Y and pyronine B.

11. The method of claim 1 , wherein the wound is an injury of the skin selected from incisions, lacerations, abrasions, puncture wounds, penetrations wounds, gunshot wounds, contusions, hematomas and crushing injuries.

12. The method of claim 1 , wherein the wound is a lesion of the oral mucosa selected from periodontitis, oral ulcers, and cold sores.

13. The method of claim 1 , wherein the wound is exposed to the actinic light at least two, three, four, five or six times, and wherein a fresh application of the composition is applied before exposure to the actinic light.

14. A method for treating bacterial infection in a wound comprising:
a) topically applying on an infected tissue of the wound a composition comprising at least one oxidant, and Eosin Y; and
b) exposing said composition to actinic light having an emission wavelength between about 400 nm and about 600 nm for a time sufficient to activate said oxidant.

15. The method according to claim 14 , wherein said composition is exposed to actinic light for a period of about 60 seconds to about 5 minutes.

16. The method according to claim 14 , wherein said composition is exposed to actinic light for a period of about 60 seconds to about 5 minutes per cm 2 of an area to be treated.

17. The method according to claim 14 , wherein the source of actinic light is in continuous motion over an area to be treated.

18. The method according to claim 14 , wherein the oxidant is selected from hydrogen peroxide, carbamide peroxide and benzoyl peroxide.

19. The method according to claim 14 , wherein the composition further comprises at least one hydrophilic gelling agent.

Assignees

• Klox Tech Inc

Inventors

• Piergallini Remigio
• Loupis Nikolaos
• Bellini Francesco

Classifications

• A61N2005/0663

  Coloured light · CPC title

• A61N2005/0662

  Visible light · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61N5/062 Primary

  Photodynamic therapy, i.e. excitation of an agent · CPC title