Artificial lung and method for manufacturing artificial lung

Patent metadata

Field	Value
Publication number	US-10758657-B2
Application number	US-201715699284-A
Country	US
Kind code	B2
Filing date	Sep 8, 2017
Priority date	Mar 10, 2015
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I):

wherein in Formula (I), R 3 represents a hydrogen atom or a methyl group, R 1 represents an alkylene group having 1 to 4 carbon atoms, and R 2 represents an alkyl group having 1 to 4 carbon atoms.

First claim

What is claimed is:

1. A method for manufacturing an artificial lung comprising a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, the method comprising:
coating the inner surfaces forming the lumens of the hollow fiber membranes or the outer surfaces with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I):

wherein in Formula (I), R 3 represents a hydrogen atom or a methyl group, R 1 represents an alkylene group having 1 to 4 carbon atoms, and R 2 represents an alkyl group having 1 to 4 carbon atoms.

2. The manufacturing method according to claim 1 ,
wherein the hollow fiber membranes are for accommodating a flow of an oxygen-containing gas inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting blood, and
the outer surfaces are coated with the polymer-containing solution.

3. The manufacturing method according to claim 1 ,
wherein the hollow fiber membranes are for accommodating blood inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting a flow of an oxygen-containing gas, and
the inner surfaces are coated with the polymer-containing solution.

4. The manufacturing method according to claim 1 ,
wherein the polymer has a weight average molecular weight of 250,000 to 600,000.

5. The manufacturing method according to claim 1 ,
wherein a wall thickness between the inner surfaces and the outer surfaces is 20 μm or more and less than 50 μm.

6. The manufacturing method according to claim 1 ,
wherein the solvent contains water and methanol in a mixing ratio of 5:1 to 99:1, based on the volume of the water and methanol.

7. The manufacturing method according to claim 1 , wherein the outer surfaces of the hollow fiber membranes are coated with the polymer-containing solution, and wherein the polymer-containing solution penetrates into a part of the outer surfaces.

8. An artificial lung, comprising:
a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material,
wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and
wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I):

wherein in Formula (I), R 3 represents a hydrogen atom or a methyl group, R 1 represents an alkylene group having 1 to 4 carbon atoms, and R 2 represents an alkyl group having 1 to 4 carbon atoms.

9. The artificial lung according to claim 8 ,
wherein the hollow fiber membranes are for accommodating a flow of an oxygen-containing gas inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting blood, and
the outer surfaces are coated with the polymer-containing solution.

10. The artificial lung according to claim 8 ,
wherein the hollow fiber membranes are for accommodating blood inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting a flow of an oxygen-containing gas, and
the inner surfaces are coated with the polymer-containing solution.

11. The artificial lung according to claim 8 ,
wherein the polymer has a weight average molecular weight of 250,000 to 600,000.

12. The artificial lung according to claim 8 ,
wherein a wall thickness between the inner surfaces and the outer surfaces is 20 μm or more and less than 50 μm.

13. The artificial lung according to claim 12 ,
wherein the wall thickness between the inner surfaces and the outer surfaces is in a range of from 25 to 30 μm.

14. The artificial lung according to claim 8 ,
wherein the solvent contains water and methanol in a mixing ratio of 5:1 to 99:1, based on the volume of the water and methanol.

15. The artificial lung according to claim 8 ,
wherein a blood plasma leakage resistance performance of the artificial lung is 15 mmHg or less.

16. The artificial lung according to claim 8 , wherein the outer surfaces of the hollow fiber membranes are coated with the polymer-containing solution, and wherein the polymer-containing solution penetrates into a part of the outer surfaces.

17. An artificial lung, comprising:
a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material,
wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces,
wherein a wall thickness between the inner surfaces and the outer surfaces is 20 μm or more and less than 50 μm,
wherein at least one of the inner surfaces or the outer surfaces is coated with a coating that contains a polymer having a structural unit represented by Formula (I):

wherein in Formula (I), R 3 represents a hydrogen atom or a methyl group, R 1 represents an alkylene group having 1 to 4 carbon atoms, and R 2 represents an alkyl group having 1 to 4 carbon atoms, and
wherein a blood plasma leakage resistance performance of the artificial lung is 15 mmHg or less.

18. The artificial lung according to claim 17 ,
wherein the hollow fiber membranes are for accommodating a flow of an oxygen-containing gas inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting blood, and
the outer surfaces are coated with the coating containing the polymer having a structural unit represented by Formula (I).

19. The artificial lung according to claim 17 ,
wherein the hollow fiber membranes are for accommodating blood inside the lumens, and the outer surfaces of the hollow fiber membranes are for contacting a flow of an oxygen-containing gas, and
the inner surfaces are coated with the coating containing the polymer having a structural unit represented by Formula (I).

20. The artificial lung according to claim 17 ,
wherein the polymer has a weight average molecular weight of 250,000 to 600,000.

21. The artificial lung according to claim 17 , wherein the outer surfaces are coated with the coating containing the polymer having a structural unit represented by Formula (I), and wherein the coating penetrates into a part of the outer surfaces.

Assignees

• Terumo Corp

Inventors

• Anzai Takao
• Sasaki Eisuke
• Ishida Norikazu

Classifications

• B01D2325/04

  Characteristic thickness · CPC title

• B01D67/0088

  Physical treatment with compounds, e.g. swelling, coating or impregnation · CPC title

• B01D69/02

  characterised by their properties · CPC title

• A61M1/3623

  Means for actively controlling temperature of blood · CPC title

• A61M2205/7536

  allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes · CPC title