Compact nanoparticles for biological applications
US-9078920-B2 · Jul 14, 2015 · US
Nanoparticles for magnetic resonance imaging applications
US10758633B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10758633-B2 |
| Application number | US-201816149082-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 1, 2018 |
| Priority date | Sep 15, 2014 |
| Publication date | Sep 1, 2020 |
| Grant date | Sep 1, 2020 |
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- Title
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- Abstract
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Abstract
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A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for magnetic resonance imaging or magnetic resonance angiography comprising: introducing a T1 contrast agent comprising a nanoparticle into a subject, wherein the nanoparticle has an inorganic core of between 2.5 and 4 nm, wherein the nanoparticle has a hydrodynamic diameter of no more than 5 nm, and wherein the nanoparticle is magnetic; and creating an imaging signal of the subject wherein the nanoparticle includes a superparamagnetic iron oxide. 2. The method of claim 1 , wherein the inorganic core has a size of between 2.5 and 3.5 nm. 3. The method of claim 2 , wherein a surface of the nanoparticle includes a zwitterionic dopamine sulfonate ligand. 4. The method of claim 2 , wherein a surface of the nanoparticle includes a DS ligand.
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Classifications
Coated nanoparticles, e.g. nanoparticles coated with organic surfactant · CPC title
- A61K49/1839Primary
the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid · CPC title
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Frequently asked questions
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- What does patent US10758633B2 cover?
- A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification A61K49/1839. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).