Topical compositions and methods of detection and treatment

Patent metadata

Field	Value
Publication number	US-10758630-B2
Application number	US-201213622666-A
Country	US
Kind code	B2
Filing date	Sep 19, 2012
Priority date	Aug 13, 2010
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.

First claim

What is claimed is:

1. A topical composition comprising a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein, wherein
the hydrophobic particles are derived from the same or different bulk hydrophobic material and each hydrophobic particle has a melting point less than the melting point of the respective bulk hydrophobic material,
the hydrophobic particles comprise a mean particle size of less than 8 nm, said hydrophilic coating consists of one or more non-ionic surfactants, and the nanoemulsion further comprises at least one pharmaceutically active agent;
wherein the bulk hydrophobic material has a melting point of from about 21° C. to about 33° C.

2. The topical composition of claim 1 , wherein the hydrophobic particles comprise a mean particle size of less than 8 nm with a polydispersity of less than about 5%.

3. The topical composition of claim 1 , wherein the hydrophobic particles comprise a mean particle size of less than 8 nm with a polydispersity of less than about 3%.

4. The topical composition of claim 1 , wherein the hydrophobic material is selected from the group consisting of a wax, butter and combinations thereof.

5. The topical composition of claim 1 , wherein the one or more non-ionic surfactants is selected from the group consisting of a fatty alcohol, a polyoxyalkylene alkyl ether, a polyoxyalkylene alkenyl ether, a polyoxyethylene glycol octylphenol ether, a polyethylene glycol alkyl ether, a polyglyceryl fatty acid ester, a fatty acid mono- or diethanolamide, a polyoxyethylene hydrogenated castor oil, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene fatty acid ester, a sorbitan ester, a sucrose ester, an alkyl-saccharide-based surfactant, an alkylamine oxide, an alkylamidoamine oxide and mixtures thereof.

6. A topical composition comprising a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein, wherein the hydrophobic particles are derived from the same or different bulk hydrophobic material and each hydrophobic particle has a melting point less than the melting point of the respective bulk hydrophobic material, said hydrophilic coating consists of one or more non-ionic surfactants; wherein the hydrophobic particles comprise a mean particle size of less than 8 nm, and wherein the nanoemulsion further comprises at least one pharmaceutically active agent relating to hirsutism or alopecia and; wherein the bulk hydrophobic material has a melting point of from about 21° C. to about 33° C.

7. The topical composition of claim 6 , wherein the hydrophobic particles comprise a mean particle size of less than 8 nm with a polydispersity of less than about 10%.

8. The topical composition of claim 6 , wherein the hydrophobic particles comprise a mean particle size of less than 8 nm with a polydispersity of less than about 5%.

9. The topical composition of claim 6 , wherein the at least one pharmaceutically active agent relating to hirsutism or alopecia comprises cyclosporine, FK506, minoxidil, or mixtures thereof.

10. The topical composition of claim 6 , wherein the hydrophobic material is selected from the group consisting of a wax, butter and combinations thereof.

11. A method for treating hirsutism or alopecia, the method comprising contacting an area of a host with a therapeutically effective amount of a topical composition comprising a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein, wherein
the hydrophobic particles are derived from the same or different bulk hydrophobic material and each hydrophobic particle has a melting point less than the melting point of the respective bulk hydrophobic material,
the hydrophobic particles comprise a mean particle size of less than 8 nm,
said hydrophilic coating consists of one or more non-ionic surfactants, and
the nanoemulsion further comprises at least one pharmaceutically active agent relating to hirsutism or alopecia;
wherein the bulk hydrophobic material has a melting point of from about 21° C. to about 33° C.

12. The method of claim 11 , wherein the at least one pharmaceutically active agent relating to hirsutism or alopecia comprises cyclosporine, FK506, minoxidil, or mixtures thereof.

13. The topical composition of claim 1 , further comprising a chemiluminescent detecting system comprising a peroxide-reactive compound and a light-emitting material.

14. The topical composition of claim 1 , further comprising a preservative.

15. The topical composition of claim 14 , wherein the preservative comprises butylparaben, propylparaben, chlorocresol, sorbic acid, benzoic acid, or combinations thereof.

16. The topical composition of claim 1 , wherein the topical composition is loaded onto a transdermal patch.

17. The method of claim 11 , wherein the topical composition is loaded onto a transdermal patch and said step of contacting an area of a host with a therapeutically effective amount of a topical composition comprises applying the transdermal patch onto the area.

18. The topical composition of claim 6 , further comprising a preservative.

19. The method of claim 11 , wherein the topical composition further comprises a preservative.

Assignees

• Univ Johns Hopkins

Inventors

• Sample Jennifer L
• Patrone Julia B
• Benkoski Jason J
• Breidenich Jennifer L
• Kelly Lisa A
• Le Huong
• Crookston James C
• Patchan Marcia W
• Garza Luis
• Calderon-Colon Xiomara
• Wolfe Joshua T
• Theodore Mellisa L
• Nelson Amanda
• Kang Sewon

Classifications

• A61K49/0078

  microemulsion, nanoemulsion · CPC title

• A61K49/0021 Primary

  the fluorescent group being a small organic molecule · CPC title

• A61K47/44

  Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) · CPC title

• A61K9/1075

  Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence) · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title