Processed food and pharmaceutical composition having watermelon sprout-derived substances as main ingredients

Patent metadata

Field	Value
Publication number	US-10758583-B2
Application number	US-201716073450-A
Country	US
Kind code	B2
Filing date	Jan 27, 2017
Priority date	Jan 29, 2016
Publication date	Sep 1, 2020
Grant date	Sep 1, 2020

Abstract

A so-called molecular-targeted drug acting on a signal transduction pathway in a cell has been developed. However, a side effect of the molecular-targeted drug is not negligible for a patient. Thus, there has been a demand for a substance that exhibits a significant growth inhibitory effect on a cancer cell with fewer side effects as a health food and a pharmaceutical composition. It has been found that a hexane extract fraction of a watermelon sprout has an effect of specifically inhibiting the cell growth of the cancer cell and such an effect is primarily caused by phytol and lutein. A processed food and pharmaceutical composition having these substances as main components can exert an anticancer action without causing side effects.

First claim

The invention claimed is:

1. A cancer cell growth inhibitor comprising an effective amount of a hexane extract fraction of a watermelon sprout.

2. The cancer cell growth inhibitor according to claim 1 , further comprising a diluent, a lubricant, a binder, a disperant, a saturant, a colorant, a sweetener, a wetting agent, and a combination thereof.

3. The cancer cell growth inhibitor according to claim 1 , further comprising a carrier.

4. A method for producing a cancer cell growth inhibitor, comprising:
washing and crushing a watermelon sprout as a pretreatment;
obtaining an extract liquid by immersing the crushed watermelon sprout in a nonpolar extraction solvent; and
filtering the extract liquid to produce the cancer cell growth inhibitor of claim 1 .

5. The method for producing a cancer cell growth inhibitor according to claim 4 , wherein
obtaining the extract liquid includes:
eluting the crushed watermelon sprout with ethanol to obtain an ethanol eluate;
redissolving the ethanol eluate with distilled water to obtain a distilled water dissolved matter; and
dissolving the distilled water dissolved matter with hexane.

6. A processed food comprising an effective amount of a hexane extract fraction of a watermelon sprout.

7. A method for producing a processed food, comprising:
washing and crushing a watermelon sprout as a pretreatment;
obtaining an extract liquid by immersing the crushed watermelon sprout in a nonpolar extraction solvent; and
filtering the extract liquid to produce the processed food of claim 6 .

8. The method for producing a processed food according to claim 7 , wherein
obtaining the extract liquid includes:
eluting the crushed watermelon sprout with ethanol to obtain an ethanol eluate;
redissolving the ethanol eluate with distilled water to obtain a distilled water dissolved matter; and
dissolving the distilled water dissolved matter with hexane.

Assignees

• Univ Kinki
• Hagihara Farm Production Inst Co Ltd

Inventors

• Itoh Tomohiro
• HASHIZUME Toshiharu

Classifications

• A61K2236/15

  involving mechanical treatment, e.g. chopping up, cutting or grinding · CPC title

• A61K2236/35

  Extraction with lipophilic solvents, e.g. Hexane or petrol ether · CPC title

• A23L33/105 Primary

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K31/047

  having two or more hydroxy groups, e.g. sorbitol · CPC title