Systems and methods for producing a chemical product

Patent metadata

Field	Value
Publication number	US-10751685-B2
Application number	US-201716094091-A
Country	US
Kind code	B2
Filing date	Apr 24, 2017
Priority date	May 2, 2016
Publication date	Aug 25, 2020
Grant date	Aug 25, 2020

Abstract

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

First claim

What is claimed is:

1. A system for producing a chemical product, the system comprising:
a chemical product production unit comprising a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow;
a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product; and
a controller comprising a program configured to implement an anti-fouling algorithm that reduces or eliminates fouling in at least one of the plurality of microfluidic modules.

2. The system according to claim 1 , wherein the system comprises one or more sensors.

3. The system according to claim 2 , wherein the controller is configured to receive data from the sensors that allow the controller to monitor a process occurring in one or more of the microfluidic modules.

4. The system according to claim 3 , wherein the controller is configured to adjust one or more parameters within the one or more of the microfluidic modules based on the received data.

5. The system according to claim 1 , wherein the chemical product is a pharmaceutical drug and the controller further comprises a program that determines an optimal drug dosage to be dispensed by the droplet dispenser based on a patient's medical history.

6. The system according to claim 1 , wherein the plurality of microfluidic modules are rearrangeable with each other.

7. The system according to claim 1 , wherein the chemical production unit is configured to screen one or more chemical pathways prior to production of the chemical product.

8. The system according to claim 1 , wherein the plurality of microfluidic modules comprise two or more of a reaction microfluidic module, a purification microfluidic module, a concentration microfluidic module, and a formulation microfluidic module.

9. The system according to claim 1 , wherein the system is configured for continuous flow through the chemical product production unit.

10. A method for producing a chemical product, the method comprising:
providing a system comprising a chemical product production unit that comprises a plurality of microfluidic modules, a droplet dispenser fluidically coupled to the chemical product production unit, a controller comprising a program configured to implement an anti-fouling algorithm that reduces or eliminates fouling in at least one of the plurality of microfluidic modules;
introducing a plurality of starting reagents to the chemical product production unit;
flowing the starting reagents through the chemical product production unit, such that a portion of a reaction occurs in each of the plurality of microfluidic modules in order to form a chemical product, under conditions implemented by the anti-fouling algorithm that reduces or eliminates fouling in at least one of the plurality of microfluidic modules; and
dispensing a droplet of the chemical product using the droplet dispenser.

11. The method according to claim 10 , wherein the system further comprises one or more sensors.

12. The method according to claim 11 , further comprising monitoring the reaction occurring in one or more of the microfluidic modules via the controller receiving data from the sensors.

13. The method according to claim 12 , further comprising adjusting, via the controller, one or more parameters within the one or more of the microfluidic modules based on the received data.

14. The method according to claim 10 , wherein the chemical product is a pharmaceutical drug and the method further comprises determining, via the controller, an optimal drug dosage to be dispensed by the droplet dispenser based on a patient's medical history that is received to the controller.

15. The method according to claim 10 , wherein the plurality of microfluidic modules are rearrangeable with each other.

16. The method according to claim 10 , wherein prior to the introducing step, the method further comprises screening, using the chemical production unit, one or more chemical pathways prior to production of the chemical product.

17. The method according to claim 10 , wherein the plurality of microfluidic modules comprise two or more of a reaction microfluidic module, a purification microfluidic module, a concentration microfluidic module, and a formulation microfluidic module.

18. The method according to claim 10 , wherein flowing is continuously flowing.

Assignees

• Purdue Research Foundation

Inventors

• Koswara Andy
• Nagy Zoltan Kalman
• Parks Conor Douglas

Classifications

• B01J2219/00968

  Type of sensors · CPC title

• B01J2219/0088

  Peltier-type elements · CPC title

• B01J2219/00909

  using filters · CPC title

• B01J2219/0097

  Optical sensors · CPC title

• B01J2219/0081

  Plurality of modules · CPC title