Polymer fiber scaffolds and uses thereof

Patent metadata

Field	Value
Publication number	US-10751293-B2
Application number	US-201615757561-A
Country	US
Kind code	B2
Filing date	Sep 6, 2016
Priority date	Sep 3, 2015
Publication date	Aug 25, 2020
Grant date	Aug 25, 2020

Abstract

A multilayered polymer composite film includes a water-soluble polymer matrix and a plurality of fibers embedded within the water soluble polymer matrix. The fibers include a water insoluble polymer material and at least one of a non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent incorporated in the water insoluble polymer material. The fibers have a rectangular cross-section, and extend the entire length of the multilayered polymer composite film.

First claim

Having described the invention, we claim:

1. A multilayered polymer composite film comprising:
a water-soluble polymer matrix and a plurality of fibers embedded within the water soluble polymer matrix; the fibers including a water insoluble polymer material and at least one of a non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent homogenously dispersed in the water insoluble polymer material, the fibers having a rectangular cross-section, and each fiber extending the entire length of the multilayered polymer composite film;
and the fibers having a surface area to volume ratio of at least about 4 m 2 /g.

2. The multilayer polymer composite film of claim 1 , wherein the hydrophobic therapeutic agent is at least partially soluble in the water insoluble polymer material.

3. The multilayer composite film of claim 1 , wherein the water soluble polymer is coextruded with the water insoluble polymer material and the at least one of a non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent.

4. The multilayer composite film of claim 3 , wherein the water insoluble polymer material is substantially immiscible with the water soluble polymer during coextrusion.

5. The multilayer composite film of claim 1 , wherein the water soluble polymeric matrix comprises polyethylene oxide and the water insoluble polymer material comprises polycaprolactone.

6. The multilayer composite film of claim 1 , wherein the non- polymeric hydrophobic therapeutic agent is clotrimazole.

7. The multilayer composite film of claim 1 , wherein the fibers comprise about 1% to about 50% by weight of the non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent.

8. A polymer nanofiber scaffold comprising:
a plurality of melt extruded polymer nanofibers, the nanofibers each having a rectangular cross-section defined in part by an encapsulating polymer material that is separated from the nanofibers, the nanofibers including a water insoluble polymer material and at least one of a non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent homogenously dispersed in the water insoluble polymer material.

9. The scaffold of claim 8 , wherein the hydrophobic therapeutic agent is at least partially soluble in the water insoluble polymer material.

10. The scaffold of claim 8 , wherein the fibers having a surface area to volume ratio of at least about 4 m 2 /g.

11. The scaffold of claim 8 , wherein a water soluble polymer is coextruded with the water insoluble polymer material and the at least one of a non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent.

12. The scaffold of claim 11 , wherein the water insoluble polymer material is substantially immiscible with the water soluble polymer during coextrusion.

13. The scaffold of claim 8 , wherein the water insoluble polymer comprises polycaprolactone.

14. The multilayer composite film of claim 8 , wherein the non- polymeric hydrophobic therapeutic agent is clotrimazole.

15. The scaffold of claim 8 , wherein the fibers comprise about 1% to about 50% by weight of the non-polymeric hydrophobic therapeutic agent or a non-polymeric hydrophobic cosmetic agent.

16. A polymer nanofiber scaffold comprising:
a plurality of melt extruded polymer nanofibers, the nanofibers each having a rectangular cross-section defined in part by an encapsulating polymer material that is separated from the nanofibers, the nanofibers including a water insoluble polymer material and clotrimazole homogenously dispersed in the water insoluble polymer matrix of the water insoluble polymer material;
wherein the fibers having a surface area to volume ratio of at least about 4 m 2 /g.

17. The scaffold of claim 16 , wherein the water insoluble polymer material comprises polycaprolactone.

Assignees

• Univ Case Western Reserve

Inventors

• Baer Eric
• Wnek Gary E
• Mofidfar Mohammad
• Wang Jia

Classifications

• A61L27/54 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title

• A61L27/48

  with macromolecular fillers · CPC title

• A61K9/7007 Primary

  Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence) · CPC title

• D01D5/08

  Melt spinning methods {(D01D5/0023 takes precedence)} · CPC title