Chromatograph device

Patent metadata

Field	Value
Publication number	US-10746709-B2
Application number	US-201616081085-A
Country	US
Kind code	B2
Filing date	Jul 6, 2016
Priority date	Mar 1, 2016
Publication date	Aug 18, 2020
Grant date	Aug 18, 2020

Abstract

A chromatograph device capable of correct measurement even if the retention times of target components change. This chromatograph device is provided with: a storage unit for storing measurement parameters for a plurality of target components, measurement conditions including measurement parameter switching times for each of two target components eluted in succession, and formulas for determining the switching times from predetermined retention times for the target components; a measurement data accumulation unit; a preceding-measurement-data determination unit for determining, at the time of sample measurement, whether there is preceding measurement data for the same column type, mobile phase type, and flow velocity; and a measurement execution unit for carrying out measurement on the basis of the measurement conditions if there is no preceding measurement data.

First claim

The invention claimed is:

1. A chromatograph device separating and measuring a plurality of components contained in a sample in terms of time, the chromatograph device comprising:
a) a storage section storing measurement parameters respectively associated with a plurality of target components assumed to be contained in a measurement target sample, measurement conditions including switching times as timings for switching the measurement parameters for each of two target components eluted in succession from a column, and formulas for determining the switching times using retention times for predetermined one or a plurality of target components among the plurality of target components;
b) a measurement data accumulation section accumulating data acquired by measurement using the chromatograph device along with information relating to a column type, a mobile phase type, and a mobile phase flow velocity in the measurement;
c) a preceding-measurement-data determination section determining, at the time of measurement target sample measurement, whether there is preceding measurement data in the measurement data accumulation section, the preceding measurement data being data obtained from measurement of the one or plurality of target components in measurement sharing the same column type, mobile phase type, and mobile phase flow velocity as the measurement; and
d) a measurement execution section carrying out measurement of the measurement target sample on the basis of the measurement conditions if there is no preceding measurement data and, if there is preceding measurement data, determining the retention times of the one or plurality of target components on the basis of the most recent preceding measurement data, determining updated switching times as new switching times on the basis of the retention times and the formulas, and carrying out measurement of the measurement target sample with the switching times included in the measurement conditions changed to the updated switching times.

2. The chromatograph device according to claim 1 , wherein the measurement parameters include a mass-to-charge ratio.

3. The chromatograph device according to claim 1 , wherein the measurement parameters include a wavelength.

Assignees

• Shimadzu Corp

Inventors

• Nakayama Daisuke

Classifications

• G01N30/8693

  Models, e.g. prediction of retention times, method development and validation · CPC title

• G01N30/8668

  using retention times · CPC title

• H01J49/004

  Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn · CPC title

• H01J49/0009

  Calibration of the apparatus · CPC title

• G01N30/72 Primary

  Mass spectrometers {(mass spectrometers per se H01J49/00)} · CPC title