Microorganisms genetically engineered to have modified N-glycosylation activity
US-9222083-B2 · Dec 29, 2015 · US
B4GALT1 cDNA variants and compositions comprising the same
US10738284B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10738284-B2 |
| Application number | US-201815996892-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 4, 2018 |
| Priority date | Jun 5, 2017 |
| Publication date | Aug 11, 2020 |
| Grant date | Aug 11, 2020 |
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Abstract
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Variant B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of detecting the presence of these molecules, methods of modulating endogenous B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of ascertaining the risk of developing cardiovascular conditions by detecting the presence or absence of the variant B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, and methods of treating cardiovascular conditions are provided herein.
First claim
Opening claim text (preview).
What is claimed is: 1. A cDNA molecule comprising a nucleotide sequence encoding a human Beta-1,4-galactosyltransferase 1 (B4GALT1) polypeptide, wherein the nucleotide sequence comprises SEQ ID NO:6. 2. A vector, comprising the nucleic acid molecule of claim 1 . 3. The vector of claim 2 , further comprising an exogenous donor sequence. 4. The vector of claim 2 , wherein the vector comprises a plasmid. 5. The vector of claim 2 , wherein the vector comprises a virus. 6. A composition, comprising the nucleic acid molecule of claim 1 and a carrier. 7. A composition comprising the vector of claim 2 and a carrier. 8. A host cell comprising the nucleic acid molecule of claim 1 . 9. A host cell comprising the vector of claim 2 . 10. The host cell of claim 8 , wherein the nucleic acid molecule is operably linked to a promoter active in the host cell. 11. The host cell of claim 10 , wherein the promoter is an inducible promoter. 12. The host cell of claim 8 , wherein the host cell is a bacterial cell, a yeast cell, or an insect cell. 13. The host cell of claim 8 , wherein the host cell is a mammalian cell.
Assignees
Inventors
Classifications
Xylosylprotein 4-beta-galactosyltransferase (2.4.1.133) · CPC title
Viral vectors · CPC title
- C12N9/1051Primary
Hexosyltransferases (2.4.1) · CPC title
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- What does patent US10738284B2 cover?
- Variant B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of detecting the presence of these molecules, methods of modulating endogenous B4GALT1 genomic, mRNA, and cDNA nucleic acid molecules, and polypeptides, methods of ascertaining the risk of developing cardiovascular conditions by detecting the presence or absence of the variant B4GALT1 genomic, mRNA, and cD…
- Who is the assignee on this patent?
- Regeneron Pharma, Univ Maryland
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1051. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 11 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).