Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy

Patent metadata

Field	Value
Publication number	US-10736974-B2
Application number	US-201515521149-A
Country	US
Kind code	B2
Filing date	Oct 22, 2015
Priority date	Oct 22, 2014
Publication date	Aug 11, 2020
Grant date	Aug 11, 2020

Abstract

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.

First claim

That which is claimed:

1. A compound:

and stereoisomers and pharmaceutically acceptable salts thereof.

Assignees

• Univ Johns Hopkins

Inventors

• Pomper Martin G
• Mease Ronnie C
• Ray Sangeeta
• Chen Ying
• Yang Xing

Classifications

• C07C323/62

  having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton · CPC title

• A61K41/0057

  Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent · CPC title

• A61K49/0052

  Small organic molecules (oligomers, polymers, dendrimers A61K49/0054) · CPC title

• A61K49/0002

  General or multifunctional contrast agents, e.g. chelated agents · CPC title

• A61K49/0032

  Methine dyes, e.g. cyanine dyes · CPC title