Controllably degradable compositions and methods

Patent metadata

Field	Value
Publication number	US-10736914-B2
Application number	US-201815882613-A
Country	US
Kind code	B2
Filing date	Jan 29, 2018
Priority date	Dec 23, 2013
Publication date	Aug 11, 2020
Grant date	Aug 11, 2020

Abstract

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.

First claim

We claim:

1. A kit for making an adhesive comprising:
a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer; and
a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups;
wherein the polymer, the dendrimer, or both the polymer and the dendrimer is substituted with one or more substituents capable of photoreversible dimerization.

2. The kit of claim 1 , further comprising a UV light source to activate or deactivate the one or more substituents capable of photoreversible dimerization.

3. The kit of claim 1 , wherein less than 75% of the one or more surface groups comprise at least one primary or secondary amine.

4. The kit of claim 1 , wherein 100% of the one or more surface groups comprise at least one primary or secondary amine.

5. The kit of claim 1 , wherein the polymer comprises dextran.

6. The kit of claim 1 , wherein the dendrimer comprises a generation 5 polyamidoamine (G5 PAMAM) dendrimer.

7. The kit of claim 1 , further comprising an applicator.

8. The kit of claim 7 , wherein the applicator comprises a multi-compartment syringe.

9. The kit of claim 8 , wherein the multi-compartment syringe comprises a mixing tip.

10. The kit of claim 1 , wherein the polymer and the dendrimer are substituted with the one or more substituents capable of photoreversible dimerization.

11. A drug delivery composition comprising:
a polymer component, wherein the polymer component comprises a polymer having three or more aldehyde groups;
a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; and
at least one drug combined with the polymer component, the dendrimer component, or both the polymer component and the dendrimer component;
wherein the polymer, the dendrimer, or both the polymer and the dendrimer is substituted with one or more substituents capable of photoreversible dimerization.

12. The composition of claim 11 , wherein 100% of the one or more surface groups comprise at least one primary or secondary amine.

13. The composition of claim 11 , wherein less than 75% of the one or more surface groups comprise at least one primary or secondary amine.

14. The composition of claim 11 , wherein the polymer comprises dextran.

15. The composition of claim 11 , wherein the dendrimer is a generation 5 polyamidoamine (G5 PAMAM) dendrimer.

16. The composition of claim 11 , wherein the polymer and the dendrimer are substituted with the one or more substituents capable of photoreversible dimerization.

Assignees

• Massachusetts Inst Technology

Inventors

• Artzi Natalie
• Edelman Elazer R
• Kelmansky Regina
• Cervantes Marc Mier

Classifications

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L24/08

  Polysaccharides {(A61L24/043 takes precedence)} · CPC title