Corneal fillers for correction of ametropia

Patent metadata

Field	Value
Publication number	US-10736731-B2
Application number	US-201615580976-A
Country	US
Kind code	B2
Filing date	Jun 13, 2016
Priority date	Jun 12, 2015
Publication date	Aug 11, 2020
Grant date	Aug 11, 2020

Abstract

A method for treating hyperopia or presbyopia in a patient, the method comprising making a cut deep in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to an anterior surface of the cornea and injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea.

First claim

What is claimed is:

1. A method for treating hyperopia or presbyopia in a patient, the method comprising:
making a cut deep in the patient's cornea with a pulsed laser to create a two-dimensional (2D) slit adjacent to and generally parallel to a posterior surface of the cornea; and
injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea,
wherein cutting the cornea comprises cutting a two-dimensional (2D) slit centered on an optical axis of the cornea,
wherein the deep cut is made at a depth of greater than 300 microns from an anterior surface of the cornea,
wherein the step of making the deep cut does not require making an incision through the corneal surface, and does not require creating a corneal flap.

2. The method of claim 1 , wherein the deep cut is made at a depth of greater than 400 microns from an anterior surface of the cornea.

3. The method of claim 1 , wherein the transparent filler material comprises a liquid filler material.

4. The method of claim 1 , wherein the transparent filler material is not cured or crosslinked so that it maintains a liquid consistency.

5. The method of claim 1 , wherein the transparent filler material comprises a hydrogel filler material.

6. The method of claim 1 , wherein the filler material comprises a refractive index greater than about 1.4 and causes an additional increase in the refractive power of the cornea due to the lenticular-shaped filler material itself of about 10 to 25 diopters.

7. The method of claim 1 , further comprising making a second, superficial cut in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to the posterior surface of the cornea, and injecting a liquid or semi-solid transparent filler material into the superficial cut in an amount sufficient to increase the curvature of an anterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 12.0 diopters due to the physical increased curvature of the anterior surface of the cornea, wherein the transparent filler material forms a corneal implant with a lenticular shape.

8. The method of claim 7 , wherein the filler material comprises a refractive index greater than about 1.4 and causes an additional increase in the refractive power of the cornea due to the lenticular-shaped filler material itself of about 10 to 25 diopters.

9. The method of claim 1 , wherein the slit is a circularly shaped 2D slit to correct spherical hyperopia.

10. The method of claim 1 , wherein the slit is a non-circularly oval shaped 2D slit to correct hyperopic astigmatism.

11. The method of claim 1 , further comprising solidifying the filler material after injecting the filler material to form a solid or semi-solid corneal implant.

12. The method of claim 11 , wherein solidifying the filler comprises crosslinking the filler.

13. The method of claim 1 , wherein the corneal implant has a refractive index of about 1.3 to 1.5.

14. The method of claim 1 , wherein the filler material comprises one or more of crosslinked hyaluronic acid (HA), dilute collagen fibrils, collagen gel, and silicone.

15. The method of claim 14 , wherein the filler material comprises ribose-crosslinked HA.

16. The method of claim 1 , further comprising fixing the corneal implant in place within the corneal cut.

17. The method of claim 16 , wherein the corneal implant is fixed in place by crosslinking components of the filler material to corneal tissue or by applying a crosslinking agent to an internal surface of the corneal cut.

Assignees

• Massachusetts Gen Hospital

Inventors

• Anderson Richard Rox
• Birngruber Reginald

Classifications

• A61F9/013 Primary

  Instruments} for compensation of ocular refraction (A61F9/008 takes precedence){; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea · CPC title

• A61P27/10

  for accommodation disorders, e.g. myopia · CPC title

• A61F9/00812

  Inlays; Onlays; Intraocular lenses [IOL] · CPC title

• A61F9/00834

  Inlays; Onlays; Intraocular lenses [IOL] · CPC title

• A61F2009/00872

  Cornea · CPC title