Ion generation using modified wetted porous materials

Patent metadata

Field	Value
Publication number	US-10732159-B2
Application number	US-201816107296-A
Country	US
Kind code	B2
Filing date	Aug 21, 2018
Priority date	Jun 3, 2011
Publication date	Aug 4, 2020
Grant date	Aug 4, 2020

Abstract

The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

First claim

What is claimed is:

1. A sample analysis system comprising:
a cartridge comprising a porous substrate that comprises a distal triangular portion that tapers to a tip and a proximal non-triangular portion that is disposed within the cartridge, and an electrode incorporated into a body of the cartridge that is connected to the proximal non-triangular portion of the porous substrate that is disposed within the cartridge.

2. The system according to claim 1 , wherein the system further comprises a mass spectrometer and the system is configured such that the cartridge is positioned with respect to an inlet of the mass spectrometer so that the tip of the porous substrate is aligned with the inlet of the mass spectrometer.

3. The system according to claim 1 , wherein the porous substrate is paper.

4. The system according to claim 3 , wherein the paper is filter paper.

5. A method for preparing a sample for analysis, the method comprising:
applying a sample to a porous substrate that comprises a distal triangular portion that tapers to a tip and a proximal non-triangular portion; and
loading the proximal non-triangular portion of the porous substrate into a cartridge comprising an electrode incorporated into a body of the cartridge such that the electrode is connected to the proximal non-triangular portion of the porous substrate that is disposed within the cartridge.

6. The method according to claim 5 , wherein the method further comprises applying voltage to at least the proximal non-triangular portion of the porous substrate to generate sample ions; and analyzing the sample ions, wherein analyzing comprises introducing the sample ions into a mass spectrometer and analyzing the sample ions in the mass spectrometer.

7. The method according to claim 5 , wherein the porous substrate is paper.

8. The system according to claim 7 , wherein the paper is filter paper.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Ouyang Zheng

Classifications

• H01J49/168 Primary

  field ionisation, e.g. corona discharge (atmospheric pressure corona discharge per se H01T19/00) · CPC title

• G01N30/91

  Application of the sample · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• H01J49/0404

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title