Benzo-fused heterocyclic derivatives useful as agonists of GPR120

Patent metadata

Field	Value
Publication number	US-10730847-B2
Application number	US-201816195553-A
Country	US
Kind code	B2
Filing date	Nov 19, 2018
Priority date	Mar 14, 2013
Publication date	Aug 4, 2020
Grant date	Aug 4, 2020

Abstract

The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.

First claim

We claim:

1. A process for making a pharmaceutical composition comprising mixing a compound selected from the group consisting of:
3-{4-[(5-Chloro-2-ethyl-1-benzofuran-7-yl)methoxy]-2,3-dimethylphenyl}propanoic acid;
3-(2,3-Dimethyl-4-{[2-methyl-5-(trifluoromethoxy)-1-benzofuran-7-yl]methoxy}phenyl)propanoic acid;
3-(7-{[2-Methyl-5-(trifluoromethoxy)-1-benzofuran-7-yl]methoxy}-2,3-dihydro-1H-inden-4-yl)propanoic acid;
3-{4-[(5-Chloro-2-methyl-1-benzofuran-7-yl)methoxy]-2,3-dimethylphenyl}propanoic acid;
3-{4-[(5-Chloro-2,6-dimethyl-1-benzofuran-7-yl)methoxy]-2,3-dimethylphenyl}propanoic acid;
3-(4-{[2-(2-Fluoroethenyl)-5-(trifluoromethoxy)-1-benzofuran-7-yl]methoxy}-2,3-dimethylphenyl)propanoic acid;
3-{4-[(6-Chloro-2-methyl-1,3-benzothiazol-4-yl)methoxy]-2,3-dimethylphenyl}propanoic acid; and
pharmaceutically acceptable salts thereof;
with a pharmaceutically acceptable carrier.

Assignees

• Janssen Pharmaceutica Nv

Inventors

• Sui Zhihua
• Subasinghe Nalin L

Classifications

• C07D493/04

  Ortho-condensed systems · CPC title

• C07D307/84

  Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen · CPC title

• C07D307/82

  with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring · CPC title

• C07D307/81

  Radicals substituted by nitrogen atoms not forming part of a nitro radical · CPC title

• C07D307/80 Primary

  Radicals substituted by oxygen atoms · CPC title