N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US-9969684-B2 · May 15, 2018 · US
N-hydroxylsulfonamide derivatives as nitroxyl donors
US10730828B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10730828-B2 |
| Application number | US-201615769171-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 18, 2016 |
| Priority date | Oct 19, 2015 |
| Publication date | Aug 4, 2020 |
| Grant date | Aug 4, 2020 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The disclosed subject matter provides N-hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound, wherein the compound is: or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising the compound of claim 1 , and at least one pharmaceutically acceptable excipient. 3. A kit for treating a disease or condition responsive to nitroxyl therapy comprising a compound of claim 1 ; and instructions for use of the kit. 4. A method of treating a cardiovascular disease responsive to nitroxyl therapy, comprising administering an effective amount of the compound of claim 1 , to a patient in need thereof.
Assignees
Inventors
Classifications
Drugs for disorders of the cardiovascular system · CPC title
- C07C311/48Primary
having nitrogen atoms of sulfonamide groups further bound to another hetero atom · CPC title
Sulfur atoms · CPC title
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring · CPC title
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
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Frequently asked questions
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- What does patent US10730828B2 cover?
- The disclosed subject matter provides N-hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical composition…
- Who is the assignee on this patent?
- Cardioxyl Pharmaceuticals Inc, Univ Johns Hopkins
- What technology area does this patent fall under?
- Primary CPC classification C07C311/48. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 04 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 10 related publications on this page (citations in our corpus or others sharing the same primary CPC).