Atherosclerosis-targeted liposome nanocarrier delivery system and preparation method therefor
US-2024424132-A1 · Dec 26, 2024 · US
US10729650B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10729650-B2 |
| Application number | US-201815875571-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 19, 2018 |
| Priority date | Jan 23, 2017 |
| Publication date | Aug 4, 2020 |
| Grant date | Aug 4, 2020 |
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A method of preparing a wound model. The method includes simulating a non-healing wound edge, simulating eschar, simulating a fibrin layer, simulating biofilm, and simulating foreign debris.
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What is claimed is: 1. A method of preparing a wound model, the method comprising: simulating a non-healing wound edge; simulating eschar; simulating a fibrin layer; simulating biofilm; and simulating foreign debris. 2. The method of claim 1 , further comprising: creating a wound on a surface of a specimen. 3. The method of claim 2 , wherein simulating a non-healing wound edge comprises: applying an orange dye to the surface of the specimen that is adjacent to the wound. 4. The method of claim 3 , further comprising: simulating slough by applying orange dye to a wound bed of the wound. 5. The method of claim 2 , wherein simulating eschar comprises: applying a black dye to a wound bed of the wound. 6. The method of claim 2 , wherein simulating the fibrin layer comprises: applying a yellow dye to a wound bed of the wound. 7. The method of claim 2 , wherein simulating biofilm comprises: applying a mixture comprising yellow orange dye, bright blue dye, yellow green dye, and a tissue adhesive to a wound bed of the wound. 8. The method of claim 7 , wherein the yellow orange dye, the bright blue dye, and the yellow green dye are microsphere dyes. 9. The method of claim 2 , wherein simulating foreign debris comprises: introducing fabric pieces into the wound. 10. A method of preparing a wound model, the method comprising: creating a wound on a surface of a specimen; simulating a non-healing wound edge by applying an orange dye to the surface of the specimen that is adjacent to the wound; simulating slough by applying orange dye to a wound bed of the wound; simulating eschar by applying a black dye to the wound bed of the wound; simulating a fibrin layer by applying a yellow dye to the wound bed of the wound; simulating biofilm by applying a mixture comprising yellow orange dye, bright blue dye, yellow green dye, and a tissue adhesive to the wound bed of the wound; and simulating foreign debris by introducing fabric pieces into the wound.
Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing · CPC title
Punch like cutting instruments, e.g. using a cylindrical or oval knife (A61B17/326 takes precedence; trepans A61B17/1695) · CPC title
Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title
Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title
substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone · CPC title
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