Methods for boosting UVA photo-protection using antioxidants

Patent metadata

Field	Value
Publication number	US-10729633-B2
Application number	US-201815939422-A
Country	US
Kind code	B2
Filing date	Mar 29, 2018
Priority date	Mar 29, 2018
Publication date	Aug 4, 2020
Grant date	Aug 4, 2020

Abstract

Methods for providing broad spectrum photo protection to skin using antioxidants that provide UVA protection to skin are described. The methods include topically applying a cosmetic composition comprising: (a) at least one antioxidant having an Oxygen Radical Absorbance Capacity (ORAC) of at least 10,000 μmol TE/g and a Hydroxyl Radical Absorbance Capacity (HORAC) of at least 2,600 μmol GAE/g; (b) at least one organic UV filter; and (c) a cosmetically acceptable carrier; wherein the cosmetic composition provides an increase in UVA PPD PF of at least 30% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a). The disclosure also relates to the cosmetic compositions useful in the described methods.

First claim

The invention claimed is:

1. A method for providing broad spectrum photo-protection to skin, the method comprising topically applying to the skin a cosmetic composition comprising:
(a) at least one antioxidant that boosts photo-protection from UVA radiation, the at least one antioxidant having:
i. an Oxygen Radical Absorbance Capacity (ORAC) of at least 10,000 μmol TE/g; and
ii. a Hydroxyl Radical Absorbance Capacity (HORAC) of at least 2,600 μmol GAE/g;

(b) at least one organic UV filter; and
(c) a cosmetically acceptable carrier;
wherein the cosmetic composition provides an increase in UVA PPD PF of at least 30% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a);
wherein the at least one antioxidant that boosts photo-protection from UVA radiation is selected from the group consisting of polydatin, phloretin, resveratrol, ferulic acid, their derivatives, and a mixture thereof; and
the cosmetic composition is free of baicalin.

2. The method of claim 1 , wherein the at least one antioxidant that boosts photo-protection from UVA radiation has a Superoxide Radical Absorbance Capacity (SORAC) of less than 200 U/mg.

3. The method of claim 1 , wherein the at least one antioxidant that boosts photo-protection from UVA radiation is polydatin and the cosmetic composition provides an increase in UVA PPD PF of at least 150% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a).

4. The method of claim 1 , wherein the at least one antioxidant that boosts photo-protection from UVA radiation is phloretin and the cosmetic composition provides an increase in UVA PPD PF of at least 50% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a).

5. The method of claim 1 , wherein the at least one antioxidant that boosts photo-protection from UVA radiation is resveratrol and the cosmetic composition provides an increase in UVA PPD PF of at least 40% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a).

6. The method of claim 1 , wherein the at least one antioxidant that boosts photo-protection from UVA radiation is ferulic acid and the cosmetic composition provides an increase in UVA PPD PF of at least 30% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a).

7. The method of claim 1 , wherein the cosmetic composition comprises from 1 to about 35 wt. % of at least one organic UV filter, based on the total weight of the cosmetic composition.

8. The method of claim 1 , wherein the total amount of antioxidant(s) of (a) is from about 0.01 to about 5 wt. %, based on the total weight of the cosmetic composition.

9. The method of claim 1 , wherein the at least one organic UV filter of (b) is selected from the group consisting of selected from the group consisting of a para-aminobenzoic acid derivative, a salicylic derivative, a cinnamic derivative, a benzophenone or an aminobenzophenone, an anthranillic derivative, a β,β-diphenylacrylate derivative, a benzylidenecamphor derivative, a phenylbenzimidazole derivative, a benzotriazole derivative, a triazine derivative, a bisresorcinyl triazine, an imidazoline derivative, a benzalmalonate derivative, a 4,4-diarylbutadiene derivative, a benzoxazole derivative, a merocyanine, malonitrile or a malonate diphenyl butadiene derivative, a chalcone, and a mixture thereof.

10. The method of claim 1 , wherein the cosmetic composition comprises at least two organic UVB filters.

11. The method of claim 1 , wherein the cosmetic composition is essentially free of inorganic UV filters.

12. The method of claim 1 , wherein the total amount of organic UV filter(s) of (b) is from about 1 to about 40 wt. %, based on the total weight of the cosmetic composition.

13. The method of claim 1 , wherein the cosmetically acceptable carrier comprises water.

14. The method of claim 13 , wherein the cosmetically acceptable carrier further comprises at least one water-soluble solvent.

15. The method of claim 1 , wherein the cosmetic composition comprises from about 40 to about 90 wt. % of the cosmetically acceptable carrier, based on the total weight of the cosmetic composition.

16. The method of claim 1 , wherein the cosmetic composition further comprises:
at least one solubilizing agent.

17. The method of claim 1 , wherein the cosmetic composition further comprises:
at least one emulsifier.

18. The method of claim 1 , wherein the cosmetic composition further comprises:
at least one silicone compound.

19. A method for providing broad spectrum photo-protection to skin, the method comprising topically applying to the skin a cosmetic composition comprising:
(a) from about 0.01 to about 5 wt. %, based on the total weight of the cosmetic composition, of at least one antioxidant that boosts photo-protection from UVA radiation selected from the group consisting of polydatin, phloretin, resveratrol, ferulic acid, their derivatives, and a mixture thereof:
(b) from about 1 to about 40 wt. %, based on the total weight of the cosmetic composition, of at least one organic UV filter; and
(c) a cosmetically acceptable carrier comprising water and at least one water-soluble solvent or solubilizing agent;
wherein the cosmetic composition provides an increase in UVA PPD PF of at least 30% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a), and
the cosmetic composition is free of baicalin.

Assignees

• Oreal

Inventors

• Pan Zhi
• Bernard Anne-Laure Suzanne
• Deng Yang

Classifications

• A61Q17/04 Primary

  Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations · CPC title

• A61K2800/522

  Antioxidants; Radical scavengers · CPC title

• A61K8/602 Primary

  Glycosides, e.g. rutin · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K8/35

  Ketones, e.g. benzophenone · CPC title