Acetazolamide ophthalmic solution

Patent metadata

Field	Value
Publication number	US-10722498-B2
Application number	US-201816344803-A
Country	US
Kind code	B2
Filing date	Jan 22, 2018
Priority date	Jan 27, 2017
Publication date	Jul 28, 2020
Grant date	Jul 28, 2020

Abstract

The present invention provides a stable, ophthalmic aqueous composition for topical administration comprising acetazolamide and an aqueous liquid capable of forming a pharmaceutically acceptable gel in situ when applied topically to a patient, said composition has the pH of less than 4.5.

First claim

The invention claimed is:

1. An aqueous ophthalmic composition comprising
(a) about 0.2% to about 2% acetazolamide based on the weight of the composition,
(b) cyclodextrin,
(c) water soluble polymer,
(d) about 0.5% to about 2% of polycarbophil based on the weight of the composition, and
(e) water.

2. The composition according to claim 1 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin.

3. The composition according to claim 1 , wherein water soluble polymer is polyvinyl alcohol.

4. The composition according to claim 1 , wherein the composition further comprises antioxidants, chelating agents, preservatives and isotonicity adjusting agents.

5. An aqueous ophthalmic composition consisting essentially of
(a) about 0.2% to about 2% acetazolamide based on the weight of the composition,
(b) hydroxypropyl-β-cyclodextrin,
(c) about 0.1% to about 1% of polyvinyl alcohol based on the weight of the composition,
(d) about 0.5% to about 2% of polycarbophil based on the weight of the composition,
(e) at least one excipient selected from antioxidant, chelating agent, preservative, isotonicity adjusting agent and
(f) water;
wherein the pH of the composition is about 4.0 to about 5.0.

Assignees

• Innovative Nano & Micro Tech Pvt Ltd Inm Tech
• Shilpa Medicare Ltd

Inventors

• Saraganachari Andanayya
• Narayanaswamy Abhilash
• Reddy Sreenivasa
• Pradeep Shivakumar

Classifications

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K31/433 Primary

  Thidiazoles · CPC title

• A61K9/0048 Primary

  Eye, e.g. artificial tears · CPC title

• A61K47/40

  Cyclodextrins; Derivatives thereof · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title