Water soluble compositions comprising purified cannabinoids

Patent metadata

Field	Value
Publication number	US-10722490-B2
Application number	US-201916700678-A
Country	US
Kind code	B2
Filing date	Dec 2, 2019
Priority date	Aug 29, 2016
Publication date	Jul 28, 2020
Grant date	Jul 28, 2020

Abstract

This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.

First claim

What is claimed is:

1. A liquid composition, comprising:
one or more purified cannabinoids;
one or more purified terpenes;
Vitamin E TPGS; and
water.

2. The liquid composition of claim 1 , comprising a ratio of Vitamin E TPGS to the one or more purified cannabinoids of about 85:15 to about 75:25 by percent mass.

3. The liquid composition of claim 1 , comprising a ratio of Vitamin E TPGS to the one or more purified cannabinoids of about 82:18 to about 78:22 by percent mass.

4. The liquid composition of claim 1 , comprising a micelle.

5. A method of making a liquid composition having one or more purified cannabinoids and one or more purified terpenes, comprising:
separating one or more purified cannabinoids and one or more purified terpenes from a cannabis plant material;
adding the one or more purified cannabinoids and the one or more purified terpenes to Vitamin E TPGS to create a mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more purified terpenes;
heating said mixture to a first temperature;
adding water to the mixture to create an aqueous formulation comprising the mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes; and
cooling the aqueous formulation to a second temperature.

6. The method of claim 5 , comprising:
sonicating the aqueous formulation comprising the mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes to create micelles;
freezing the aqueous formulation comprising the mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes;
lowering pressure of the aqueous formulation comprising the mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes;
removing water from the aqueous formulation comprising the mixture of Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes to create a dry powder; and
adding water to the dry powder to create a liquid cannabinoid composition comprising Vitamin E TPGS and the one or more purified cannabinoids and one or more terpenes.

7. The method of claim 6 , wherein the dry powder comprises reverse micelles.

8. The method of claim 6 , wherein the first temperature is between 70-90 degrees Celsius; and wherein the second temperature is between 0-50 degrees Celsius.

9. The liquid composition of claim 1 , wherein the one or more purified cannabinoids is THCA, CBC, THC, CBN, CBD, CBG, CBGA, CBDA, or a combination thereof.

10. The liquid composition of claim 1 , wherein the one or more purified cannabinoids is CBD, THC, THCV, or a combination thereof.

11. The liquid composition of claim 10 , wherein the combination comprises THC, CBD and THCV.

12. The liquid composition of claim 1 , wherein the one or more purified terpenes is linalool, alpha-pinene, alpha-humulene, terpinolene, eucalyptol, pulegone, terpineol, beta-caryophyllene, cymene, or a combination thereof.

13. The liquid composition of claim 11 , wherein the liquid composition comprises beta-caryophyllene, linalool, and cymene as purified terpenes.

14. The liquid composition of claim 4 , wherein the one or more cannabinoids and/or the one or more terpenes are contained within the micelles.

15. The liquid composition of claim 1 , comprising a ratio of Vitamin E TPGS to a combined amount of the one or more purified cannabinoids and the one or more purified terpenes of about 85:15 to about 75:25 by percent mass.

16. The liquid composition of claim 1 , comprising a ratio of Vitamin E TPGS to a combined amount of the one or more purified cannabinoids and the one or more purified terpenes of about 85:15 to about 75:25 by percent mass.

17. The method of claim 6 , wherein adding water to the dry powder creates a liquid cannabinoid composition comprising Vitamin E TPGS and between 5 to 20 mg of the one or more purified cannabinoids and one or more terpenes per mL of water.

Assignees

• Canopy Growth Corp

Inventors

• Levy Kurt Aron

Classifications

• A61K36/3482

  Cannabis · CPC title

• A61K31/658

  o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol · CPC title

• A61K47/22

  Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones · CPC title

• A61K31/015

  carbocyclic · CPC title

• A61K31/01

  Hydrocarbons · CPC title