Aqueous oral care compositions

Patent metadata

Field	Value
Publication number	US-10722446-B2
Application number	US-201114362908-A
Country	US
Kind code	B2
Filing date	Dec 15, 2011
Priority date	Dec 15, 2011
Publication date	Jul 28, 2020
Grant date	Jul 28, 2020

Abstract

Described herein are aqueous oral care compositions comprising (a) an effective amount of a basic amino acid in free or orally acceptable salt form; and (b) a polymer system comprising (i) a cellulosic polymer, (ii) a gum polymer, and (iii) a polyacrylate polymer or co-polymer; and methods of making and using the same.

First claim

The invention claimed is:

1. An aqueous oral care composition comprising
a) 0.5 to 2% by weight of a basic amino acid in free or orally acceptable salt form; and
b) a polymer system comprising (i) 0.01 to 0.5% by weight of carboxy methyl cellulose, (ii) 0.01 to 0.5% by weight of xanthan gum, and (iii) 0.01 to 0.5% by weight of a polyacrylate polymer or co-polymer selected from a carbomer or a homo- or a copolymer of acrylic acid crosslinked with a polyalkenyl polyether;
wherein the basic amino acid is selected from the group consisting of arginine hydrochloride, arginine phosphate, arginine bicarbonate, and combinations thereof;
and wherein the composition comprises 50-90% by weight of water; and wherein the composition further comprises a fluoride source in an amount effective to provide about 225 ppm of fluoride;
wherein the composition does not comprise an abrasive; and
wherein the composition has a flow rate index of about 0.5 to about 0.6 and a G′/G″ ratio of greater than 0.5.

2. The composition of claim 1 , wherein the fluoride source is selected from sodium fluoride; sodium monofluorophosphate; and a combination thereof.

3. The composition of claim 1 , wherein the fluoride source comprises sodium fluoride.

4. The composition of claim 1 wherein the basic amino acid is L-arginine in orally acceptable salt form.

5. The composition of claim 1 , further comprising a buffering agent.

6. The composition of claim 1 , further comprising a humectant.

7. The composition of claim 1 , further comprising an antibacterial agent.

8. The composition of claim 1 wherein the polyacrylate polymer or co-polymer is a carbomer.

9. The composition of claim 1 wherein the polyacrylate polymer or co-polymer is selected from homo- and copolymers of acrylic acid crosslinked with a polyalkenyl polyether.

10. The aqueous oral care composition of claim 1 , wherein the composition delivers an amount of fluoride effective to provide a step height difference of less than 0.25 microns, when evaluated using the Hooper protocol.

11. The composition of claim 10 , wherein the fluoride source is present in the amount of about 0.05%, by weight, of the composition.

12. A method of reducing dental enamel erosion comprising administering a composition according to claim 1 to the oral cavity of subject in need thereof.

13. The method of claim 12 , wherein the administering comprises rinsing for from 15 to 60 seconds.

14. The composition of claim 1 for use in a method of reducing dental enamel erosion.

15. The composition of claim 14 wherein the method comprises administering the composition to the oral cavity of a subject in need thereof.

16. The composition of claim 15 wherein the method further comprises rinsing for from 15 to 60 seconds.

Assignees

• Pimenta Paloma
• Miksa Davide
• Pilch Shira
• Rege Aarti
• Sullivan Richard
• Colgate Palmolive Co

Inventors

• Pimenta Paloma
• Miksa Davide
• Pilch Shira
• Rege Aarti
• Sullivan Richard

Classifications

• A61K2800/594

  Mixtures of polymers · CPC title

• A61K8/73

  Polysaccharides · CPC title

• A61K8/731

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61K8/21

  Fluorides; Derivatives thereof · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title