Bubble jetting member and method for producing same, gas/liquid jetting member and method for producing same, localized ablation device and localized ablation method, injection device and injection method, plasma-bubble jetting member, and therapeutic device and therapeutic method

Patent metadata

Field	Value
Publication number	US-10716610-B2
Application number	US-201314382012-A
Country	US
Kind code	B2
Filing date	Mar 1, 2013
Priority date	Mar 2, 2012
Publication date	Jul 21, 2020
Grant date	Jul 21, 2020

Abstract

Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma.
Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage. By further providing an outside shell part at the outer periphery of the shell part, bubbles onto which a solution containing an injection substance has been adsorbed can be ejected, and the injection substance can be introduced during localized ablation of the process target. Additionally, by including a pair of electrodes formed from a conducting material, for generating a plasma in an inert gas, a liquid flow passage through which a liquid flows, and a microscopic flow passage for flow of an inert gas, an inert gas containing a plasma, and bubbles of inert gas containing a plasma, the liquid flow passage and the microscopic flow passage connecting at the downstream side from a section in which plasma is generated in the microscopic flow passage, bubbles containing a plasma can be generated, and can maintain a plasma state even in liquid, whereby therapy of biological tissue can be effected with the plasma.

First claim

The invention claimed is:

1. A gas/liquid jetting member comprising:
a bubble jetting member, comprising:
a solid core formed from a conductive material;
a shell part formed from an insulating material, the shell part covering the solid core and comprising a section that extends from a tip of the solid core;
an internal space formed between the extended section of the shell part and the tip of the solid core; and
a first opening formed at a tip of the extended section of the shell part; wherein
the internal space occupies a chamber defined by the tip of the solid core and the shell part, the chamber being enclosed except for the first opening; and

an outside shell part formed to the outside of the shell part of the bubble jetting member, the outside shell part:
having an axis coaxial with the center axis of the shell part,
being formed at a position away from the shell part so that an external space is left therebetween; and
having a second opening formed at a tip of the outside shell part, wherein

the external space extends at least between the first opening formed at the tip of the extended section of the shell part and the second opening formed at the tip of the outside shell part.

2. The gas/liquid jetting member according to claim 1 , wherein the section of the outside shell part formed to the outside of the extended section of the shell part is tapered.

3. The gas/liquid jetting member according to claim 1 or 2 , including a solution containing an injection substance, in the external space between the shell part and the outside shell part.

4. The gas/liquid jetting member according to claim 1 or 2 , further comprising an electrode part that, together with the solid core of the gas/liquid jetting member, constitutes a pair of electrodes,
the electrode part being provided as a separate element from the solid core, the shell part, and
the outside shell part of the gas/liquid jetting member, on an outer face of the shell part, or on an inner face of the outside shell part.

5. The gas/liquid jetting member according to claim 1 or 2 , wherein the gas/liquid jetting member is provided with an oscillator.

6. An injection device employing the gas/liquid jetting member according to claim 1 or 2 .

7. A localized ablation device employing the gas/liquid jetting member according to claim 1 or 2 .

8. The gas/liquid jetting member according to claim 1 , wherein the extended section of the shell part is tapered.

9. An injection method, comprising:
introducing a solution containing an injection substance between the shell part and the outside shell part of the injection device according to claim 6 ;
immersing the injection device in another solution;
applying a high-frequency electrical pulse to a core of a pair of electrodes which are constituted by the solid core and an electrode part of the injection device, to eject from a tip of the gas/liquid jetting member bubbles onto which the solution containing the injection substance is adsorbed; and
introducing the injection substance into a process target, while subjecting the process target to localized ablation with the bubbles.

10. A localized ablation method, comprising:
immersing the localized ablation device according to claim 7 in a solution;
applying a high-frequency electrical pulse to a core of a pair of electrodes which are constituted by the solid core and an electrode part of the localized ablation device, to eject bubbles from a tip of the gas/liquid jetting member; and
processing a process target with the bubbles.

Assignees

• Japan Science & Tech Agency

Inventors

• Yamanishi Yoko
• Sakuma Shinya
• KURIKI Hiroki
• Arai Fumihito

Classifications

• A61M5/3007

  with specially designed jet passages at the injector's distal end · CPC title

• A61M5/2066

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61B17/3203

  Fluid jet cutting instruments · CPC title

• A61M5/30

  Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules · CPC title

• C12M35/04

  Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli · CPC title