Methods Of Mediating Macrophage Phenotypes
US-2015147300-A1 · May 28, 2015 · US
Composition for inhibiting survival or growth of tubercle bacillus by adjusting polarization of macrophage, and method using same
US10709765B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10709765-B2 |
| Application number | US-201716315607-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 4, 2017 |
| Priority date | Jul 5, 2016 |
| Publication date | Jul 14, 2020 |
| Grant date | Jul 14, 2020 |
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- Title
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Abstract
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The present invention provides a composition for inhibiting the survival or growth of a tubercle bacillus, containing a material which induces the polarization of a macrophage into an M1 macrophage, and a method for inhibiting the survival or growth of the tubercle bacillus by using the composition.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition for inhibiting the survival or proliferation of Mycobacterium tuberculosis , the composition comprising: a material inducing the polarization of macrophages into M1 macrophages, and at least one anti-tuberculosis drug selected from the group consisting of rifampicin, isoniazid, ethambutol, pyrazinamide, and analogues thereof. 2. The composition of claim 1 , wherein the material inducing polarization of macrophages into M1 macrophages comprises at least one selected from the group consisting of lipopolysaccharide, interferon-gamma, IL-6, and TNF-α. 3. The composition of claim 1 , wherein the material inducing the polarization of macrophages into M1 macrophages includes 1-20 ng/ml of lipopolysaccharide and 1-20 ng/ml of interferon-gamma.
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Classifications
Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title
- A61K35/15Primary
Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells (presenting a specific antigen A61K39/00; therapeutic combinations of antibodies, or fragments thereof, and blood-derived cells A61K39/00) · CPC title
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title
Cytokines; Lymphokines; Interferons · CPC title
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- What does patent US10709765B2 cover?
- The present invention provides a composition for inhibiting the survival or growth of a tubercle bacillus, containing a material which induces the polarization of a macrophage into an M1 macrophage, and a method for inhibiting the survival or growth of the tubercle bacillus by using the composition.
- Who is the assignee on this patent?
- Iac In Nat Univ Chungnam
- What technology area does this patent fall under?
- Primary CPC classification A61K35/15. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 14 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).