System and method for micro laser particles

Patent metadata

Field	Value
Publication number	US-10707649-B2
Application number	US-201716306278-A
Country	US
Kind code	B2
Filing date	Jun 5, 2017
Priority date	Jun 3, 2016
Publication date	Jul 7, 2020
Grant date	Jul 7, 2020

Abstract

Disclosed are photonic particles and methods of using particles in biological samples. The particles are configured to emit laser light when energetically stimulated by, e.g., a pump source. The particles may include a gain medium with inorganic materials, an optical cavity with high refractive index, and a coating with organic materials. The particles may be smaller than 3 microns along their longest axes. The particles may attach to each other to form, e.g., doublets and triplets. The particles may be injection-locked by coupling an injection beam into a particle while pumping so that an injection seed is amplified to develop into laser oscillation. A microscopy system may include a pump source, beam scanner, spectrometer with resolution of less than 1 nanometer and acquisition rate of more than 1 kilohertz, and spectral analyzer configured to distinguish spectral peaks of laser output from broadband background.

First claim

The invention claimed is:

1. A photonic particle configured to emit light when energetically excited, the particle comprising:
a gain medium including one or more inorganic materials;
an optical cavity situated about the gain medium, the optical cavity having a refractive index greater than 2; and
a coating covering at least part of the optical cavity, the coating including one or more organic materials.

2. The particle of claim 1 , wherein the particle has a three-dimensional shape that is not greater than 3 micrometers along its longest axis.

3. The particle of claim 1 , wherein the optical cavity has a refractive index of at least 3.5.

4. The particle of claim 1 , configured to emit light comprising a spectrum having one or more narrowband peaks defined by cavity modes of the optical cavity.

5. The particle of claim 4 , wherein a spectral width of each peak is no broader than 1 nm.

6. The particle of claim 1 , wherein the particles is a quantum-well micro disk laser.

7. The particle of claim 1 , wherein the particle comprises a semiconductor sphere.

8. The particle of claim 1 , wherein the gain medium comprises a plurality of fluorescent dye particles.

9. The particle of claim 1 , wherein the optical cavity includes one or more dielectric materials.

10. The particle of claim 1 , wherein the optical cavity includes one or more metals.

11. The particle of claim 1 , wherein the coating is biologically inert such that the particle is biocompatible.

12. The particle of claim 1 , wherein the coating is configured to be chemically binding within a biological sample.

13. The particle of claim 1 , wherein the coating is a dielectric shell.

14. The particle of claim 1 , wherein the coating includes one or more polymers.

15. The particle of claim 1 , wherein the coating includes one or more proteins.

16. The particle of claim 1 , wherein the coating covers substantially all of the optical cavity.

17. The particle of claim 1 , wherein a round trip length of the optical cavity supports a sufficiently large number of active gain elements in the gain medium, and the optical loss of the optical cavity is sufficiently low, such that the photonic particle supports laser oscillation.

18. The particle of claim 1 , configured to generate laser light when optically stimulated.

19. A set of two or more particles of claim 1 , each particle configured to emit light comprising a spectrum having one or more narrowband peaks defined by cavity modes of the optical cavity, wherein lasing wavelengths of the particles are different from each other.

20. The set of two or more particles of claim 19 , wherein a difference of lasing wavelengths is substantially equal to or greater than a spectral width of the lasing peaks.

21. A set of two or more particles of claim 1 , comprising at least two particles attached to each other.

22. The set of two or more particles of claim 21 , each particle configured to emit light comprising a spectrum having one narrowband peak defined by cavity modes of the optical cavity, wherein lasing wavelengths of the particles are substantially different from each other.

23. A method of emitting laser light within a biological sample, the method comprising placing one or more photonic particles in the biological sample, the photonic particles being configured to emit laser light when energetically excited or stimulated, one or more of the photonic particles comprising:
a gain medium including one or more inorganic materials;
an optical cavity situated about the gain medium, the optical cavity having a refractive index greater than 2; and
a coating covering at least part of the optical cavity, the coating including one or more organic materials.

24. The method of claim 23 , further comprising optically exciting or stimulating the photonic particles using a light source.

25. The method of claim 23 , further comprising using a pump light source to emit an excitation light at photonic particles from outside the biological sample to excite the photonic particles to emit the laser light.

26. The method of claim 23 , wherein the biological sample is a living organism.

27. A photonic particle configured to emit light when energetically excited, the particle comprising:
a gain medium including one or more inorganic materials;
an optical cavity situated about the gain medium, the optical cavity having a refractive index greater than 2; and
a coating covering at least part of the optical cavity, the coating including one or more inorganic materials.

28. The particle of claim 1 , wherein the coating includes one or more peptides.

29. The particle of claim 1 , wherein the coating includes one or more antibodies.

30. The particle of claim 1 , wherein the coating includes one or more nucleic acids.

31. The particle of claim 1 , wherein the coating includes one or more pharmaceutically-active agents.

32. A set of two or more particles of claim 1 , each particle configured to emit light comprising a spectrum having one narrowband peak defined by cavity modes of the optical cavity, wherein lasing wavelengths of the particles are substantially identical within the spectral width of the lasing peaks.

33. A set of two or more particles of claim 1 , each particle configured to emit light comprising a spectrum having one or more narrowband peaks defined by cavity modes of the optical cavity, wherein lasing wavelengths of the particles are substantially identical.

Assignees

• Massachusetts Gen Hospital

Inventors

• Yun Seok Hyun

Classifications

• H01S2301/176

  Specific passivation layers on surfaces other than the emission facet · CPC title

• H01S5/4025

  Array arrangements, e.g. constituted by discrete laser diodes or laser bar (H01S5/42 takes precedence) · CPC title

• H01S5/40

  Arrangement of two or more semiconductor lasers, not provided for in groups H01S5/02 - H01S5/30 (H01S5/50 takes precedence) · CPC title

• H01S5/36

  comprising organic materials · CPC title

• H01S5/34313 Primary

  with a well layer having only As as V-compound, e.g. AlGaAs, InGaAs · CPC title