Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
US-2024131053-A1 · Apr 25, 2024 · US
US10702545B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10702545-B2 |
| Application number | US-201515512704-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 18, 2015 |
| Priority date | Sep 22, 2014 |
| Publication date | Jul 7, 2020 |
| Grant date | Jul 7, 2020 |
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An object of the present invention is to provide a carbohydrate-derived energy supplying agent having slow digestibility and sustained digestibility functions. According to the present invention, there is provided a slowly digestible, sustained-type energy supplying agent comprising a saccharide composition which satisfies the following (A), (B), (C), and (D): (A) a percentage of α-1,6 bonds relative to all glycosidic bonds is 60% or more; (B) a content of saccharides having a degree of polymerization of 1 and 2 relative to all saccharides is 9 mass % or less; (C) a content of saccharides having a degree of polymerization within a range of 3 to 30 relative to all saccharides is 41 mass % or more; and (D) a content of saccharides having a degree of polymerization of 31 or more relative to all saccharides is 50 mass % or less.
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The invention claimed is: 1. A method for energy supply to a mammal, which comprises feeding or administering to the mammal a saccharide composition, wherein said saccharide composition is a dextran degradation product or a fractionated product thereof, or a dextran-producing enzyme reaction product or a fractionated product thereof, which satisfies the following (A), (B), (C), (D), and (E): (A) a percentage of α-1,6 bonds relative to all glycosidic bonds being 60% or more; (B) a content of saccharides having a degree of polymerization of 1 and 2 relative to all saccharides being 9 mass % or less; (C) a content of saccharides having a degree of polymerization within a range of 3 to 30 relative to all saccharides being 41 mass % or more; (D) a content of saccharides having a degree of polymerization of 31 or more relative to all saccharides being 40 mass % or less; and (E) a content of saccharides having a degree of polymerization within a range of 10 to 30 relative to all saccharides being 20 mass % or more, and wherein the saccharide composition is (i) slowly digestible and (ii) has a slow change in blood glucose levels upon intake. 2. The method according to claim 1 , wherein the saccharide composition comprises 3 mass % or more of saccharides having a degree of polymerization within a range of 3 to 9 relative to all saccharides. 3. The method according to claim 1 , wherein the saccharide composition comprises 30 mass % or more of saccharides having a degree of polymerization within a range of 10 to 30 relative to all saccharides. 4. The method according to claim 1 , wherein, in the above (A), (A-1) the percentage of α-1,6 bonds relative to all glycosidic bonds is 90% or more. 5. The method according to claim 1 , wherein, in the above (A), (A-2) the percentage of α-1,6 bonds relative to all glycosidic bonds is 60 to 99%, and a percentage of α-1,4 bonds relative to glycosidic bonds other than the α-1,6 bonds is 80% or more. 6. The method according to claim 1 , wherein the mammal is a human. 7. The method according to claim 6 , wherein the human is a diabetic patient. 8. The method according to claim 1 , wherein the saccharide composition is part of a food or beverage product. 9. A method for treating a disease or a symptom for which slowing a change in blood glucose level is therapeutically effective, comprising feeding or administering to a mammal a saccharide composition, wherein said saccharide composition is a dextran degradation product or a fractionated product thereof, or a dextran-producing enzyme reaction product or a fractionated product thereof, which satisfies the following (A), (B), (C), (D) and (E): (A) a percentage of α-1,6 bonds relative to all glycosidic bonds being 60% or more; (B) a content of saccharides having a degree of polymerization of 1 and 2 relative to all saccharides being 9 mass % or less; (C) a content of saccharides having a degree of polymerization within a range of 3 to 30 relative to all saccharides being 41 mass % or more; (D) a content of saccharides having a degree of polymerization of 31 or more relative to all saccharides being 50 mass % or less; and (E) a content of saccharides having a degree of polymerization within a range of 10 to 30 relative to all saccharides being 20 mass % or more, and wherein the saccharide composition is (i) slowly digestible and (ii) has a slow change in blood glucose levels upon intake. 10. The method according to claim 9 , wherein the saccharide composition comprises 3 mass % or more of saccharides having a degree of polymerization within a range of 3 to 9 relative to all saccharides. 11. The method according to claim 9 , wherein the saccharide composition comprises 30 mass % or more of saccharides having a degree of polymerization within a range of 10 to 30 relative to all saccharides. 12. The method according to claim 9 , wherein, in the above (A), (A-1) the percentage of α-1,6 bonds relative to all glycosidic bonds is 90% or more. 13. The method according to claim 9 , wherein, in the above (A), (A-2) the percentage of α-1,6 bonds relative to all glycosidic bonds is 60 to 99%, and a percentage of α-1,4 bonds relative to glycosidic bonds other than the α-1,6 bonds is 80% or more. 14. The method according to claim 9 , wherein the saccharide composition is part of a food or beverage product.
Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032) · CPC title
for hyperglycaemia, e.g. antidiabetics · CPC title
Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages · CPC title
Dextrans · CPC title
Dextran; Derivatives thereof · CPC title
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