Dual amplitude modulation and polarization frequency modulation as well as compensation for noninvasive glucose monitoring

Patent metadata

Field	Value
Publication number	US-10702197-B2
Application number	US-201715656146-A
Country	US
Kind code	B2
Filing date	Jul 21, 2017
Priority date	Jul 26, 2016
Publication date	Jul 7, 2020
Grant date	Jul 7, 2020

Abstract

An embodiment relates generally to an improved method and apparatus for modulating the amplitude and rotation of the plane of polarization of linearly polarized light for multiple uses but primarily as part of a noninvasive glucose monitoring system. As compared to previous monitoring systems, an embodiment provides faster monitoring while maintaining or even reducing noise and minimizing system complexity. Embodiments described herein address these concerns with a modulation and compensation approach that both uses a single high speed device and also modulation of the lasers.

First claim

What is claimed is:

1. A system to measure glucose levels in an aqueous humor of an eye, the system comprising:
two light sources to generate two light beams at different wavelengths;
two polarizers to respectively linearly polarize each of the light beams;
two polarization modulation modules to respectively modulate the rotation of a plane of polarization of each of the linearly polarized light beams, each of the polarization modulation modules comprising: (a)(i) a magnetically permeable core having an air gap; (a)(ii) a magneto-optic material at least partially disposed within the air gap; and (a)(iii) at least one conductor wrapped around a portion of the magnetically permeable core; and
a detector module;
wherein with each polarization modulation module when a current is passed through at least one conductor (b)(i) a magnetic field is generated and propagates through the magnetically permeable core, and (b)(ii) the magnetic field rotates the plane of polarization of the linearly polarized light for the light source, when the linearly polarized light is directed through the magneto-optic material, generating a modulated light beam;
wherein the detector unit is to (c)(i) receive the modulated light beams after the modulated light beams are passed through the aqueous humor of the eye, and (c)(ii) detect a change in the plane of polarization of each of the modulated light beams in response to a concentration of glucose in the aqueous humor.

2. The system of claim 1 , wherein the magneto-optic material includes a terbium-gallium-garnet (TGG) crystal.

3. The system of claim 2 , wherein the TGG crystal is approximately 1 centimeter long.

4. The system of claim 3 , wherein with each polarization modulation module a first one of the one or more conductors is to carry an alternating current and a second one of the one or more conductors is to carry a direct current.

5. The system of claim 4 , wherein the alternating current has a frequency between 1 kHZ and 1 MHz.

6. The system of example 4, wherein the alternating current is to generate an alternating magnetic field.

7. The system of example 6, wherein the alternating magnetic field is to modulate the rotation of the plane of polarization of the light between a lower angle of rotation and an upper angle of rotation.

8. The system of claim 4 , wherein the direct current is supplied by a feedback loop to produce a magnetic field that compensates for the rotation from the glucose signal.

9. The system of claim 1 wherein the light sources are modulated at frequencies between 10 KHz to 1 MHz.

10. The system of claim 1 wherein the light sources are heterodyned with the polarization modulation modules.

11. A method of measuring glucose levels in an aqueous humor of an eye comprising:
generating a linearly polarized light beam;
passing the linearly polarized light beam through a polarization modulation device comprising: (a)(i) a magnetically permeable core; (a)(ii) an aperture extending through at least a portion of the magnetically permeable core; (a)(iii) a magneto-optic material at least partially disposed within the through hole; and (a)(iv) a conductor wrapped around a portion of the magnetically permeable core;
passing an alternating current through the conductor to generate an alternating magnetic field that propagates through the magnetically permeable core and modulates a rotation of a plane of polarization of the linearly polarized light passed through the polarization modulation device to generate a modulated light beam;
passing the modulated light beam through the aqueous humor; and
detecting a change in the plane of polarization of the modulated light beam in response to a concentration of glucose in the aqueous humor.

12. The method of claim 11 , wherein the magneto-optic material is terbium-gallium-garnet (TGG) crystal.

13. The method of claim 12 , wherein the TGG is approximately 1 centimeter long.

14. A system to measure glucose levels in an aqueous humor of an eye, the system comprising:
a light source to generate a light beam;
a polarizer to linearly polarize the light beam;
a polarization modulation module to modulate a rotation of a plane of polarization of the linearly polarized light beam, the polarization modulation module comprising: (a)(i) a magnetically permeable core having an air gap; (a)(ii) a magneto-optic material at least partially disposed within the air gap; and (a)(iii) at least one conductor wrapped around a portion of the magnetically permeable core; and
a detector module;
wherein when a current is passed through the at least one conductor (b)(i) a magnetic field is generated and propagates through the magnetically permeable core, and (b)(ii) the magnetic field rotates the plane of polarization of the linearly polarized light, when the linearly polarized light is directed through the magneto-optic material, generating a modulated light beam;
wherein the detector unit is to (c)(i) receive the modulated light beam after the modulated light beam is passed through the aqueous humor, and (c)(ii) detect a change in the plane of polarization of the modulated light beam in response to a concentration of glucose in the aqueous humor.

15. The system of claim 14 , wherein the magneto-optic material includes a terbium-gallium-garnet (TGG) crystal.

16. The system of claim 15 , wherein the TGG crystal is approximately 1 centimeter long.

17. The system of claim 16 , wherein a first one of the one or more conductors is to carry an alternating current and a second one of the one or more conductors is to carry a direct current.

18. The system of claim 17 , wherein the alternating current has a frequency between 1 kHZ and 1 MHz.

19. The system of example 17, wherein the alternating current is to generate an alternating magnetic field.

20. The system of example 19, wherein the alternating magnetic field is to modulate the rotation of the plane of polarization of the light between a lower angle of rotation and an upper angle of rotation.

Assignees

• Texas A&M Univ System
• Texas A & M Univ Sys

Inventors

• Cote Gerard L
• Grunden Daniel T
• Malik Bilal H
• Pirnstill Casey
• Thomas Iii Erwin

Classifications

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• G02F1/092

  Operation of the cell; Circuit arrangements · CPC title

• A61B5/14558 Primary

  by polarisation · CPC title

• A61B2562/0238

  Optical sensor arrangements for performing transmission measurements on body tissue · CPC title

• A61B5/6821

  Eye · CPC title