Ion guide

Patent metadata

Field	Value
Publication number	US-10699889-B2
Application number	US-201716301428-A
Country	US
Kind code	B2
Filing date	May 15, 2017
Priority date	May 13, 2016
Publication date	Jun 30, 2020
Grant date	Jun 30, 2020

Abstract

Disclosed herein is an ion guide comprising a plurality of axially stacked plates, wherein at least some or all of said plates comprise: a first electrically conductive portion; and a second electrically conductive portion, wherein the second electrically conductive portion is electrically isolated from the first electrically conductive portion, the first and second electrically conductive portions being shaped and arranged relative to each other so as to define an opening through which ions are axially transmitted in use; wherein, in use, a first AC or RF voltage is applied to the first electrically conductive portion and a second AC or RF voltage is applied to the second electrically conductive portion in order to confine ions radially within said opening. The first and second electrically conductive portions (1, 2) may be separately formed and interleaved within the ion guide to define the plates. Alternatively the first (41, 43) and second (42, 44) electrically conductive portions may be printed onto a common substrate (4).

First claim

The invention claimed is:

1. An ion guiding device having a length, where in use ions are transmitted along the length of the ion guiding device, the ion guiding device comprising a plurality of axially stacked plates, stacked axially along the length of the ion guiding device in the direction that ions are transmitted in use wherein at least some or all of said plates comprise:
a first electrically conductive portion; and
a second electrically conductive portion, wherein the second electrically conductive portion is electrically isolated from the first electrically conductive portion, the first and second electrically conductive portions being shaped and arranged relative to each other so as to define an opening through which ions are axially transmitted in use;
wherein each of the plates and/or each of the electrically conductive portions are individually mounted between a pair of spaced-apart support plates; and
wherein, in use, a first AC or RF voltage is applied to the first electrically conductive portion and a second AC or RF voltage is applied to the second electrically conductive portion in order to confine ions radially within said opening, wherein said first AC or RF voltage is applied via only one of said spaced-apart support plates and wherein said second AC or RF voltage is applied via only the other of said spaced-apart support plates.

2. An ion guiding device as claimed in claim 1 , wherein said first electrically conductive portion and said second electrically conductive portion are separately formed and interleaved with each other to define said plates.

3. An ion guiding device as claimed in claim 1 , wherein said first electrically conductive portion and said second electrically conductive portion are formed on a single substrate, optionally wherein said first electrically conductive portion and said second electrically conductive portion are printed on said substrate.

4. An ion guiding device as claimed in claim 1 , wherein said first electrically conductive portion and said second electrically conductive portion are shaped and arranged relative to each other such that, in use, said first AC or RF voltage and said second AC or RF voltage generate a multipole confining field, and optionally a quadrupole confining field.

5. An ion guiding device as claimed in claim 1 , wherein said first electrically conductive portion comprises a first electrical connection portion for receiving said first AC or RF voltage and wherein said second electrically conductive portion comprises a second electrical connection portion for receiving said second AC or RF voltage, wherein said first electrical connection portion and said second electrical connection portion are located on opposite sides of the ion guiding device.

6. An ion guiding device as claimed in claim 1 , wherein each of said plurality of axially stacked plates further comprises a DC electrical connection for connecting said plate to one or more DC voltage source for generating, in use, one or more DC voltages or fields, and optionally enabling one or more transient DC voltages or potential wells to be applied to said plates, for transporting or urging ions axially along the ion guiding device.

7. A mass or ion mobility spectrometer comprising an ion guiding device as claimed in claim 1 .

8. A method of constructing an ion guiding device having a length, where in use ions are transmitted along the length of the ion guiding device, the method comprising:
providing a plurality of plates, wherein at least some or all of said plates comprise a first electrically conductive portion and a second electrically conductive portion, the second electrically conductive portion being electrically isolated from the first electrically conductive portion, so that, in use, a first AC or RF voltage can be applied to the first electrically conductive portion(s) and a second AC or RF voltage can be applied to the second electrically conductive portion(s) in order to confine ions within said ion guiding device,
wherein the first and second electrically conductive portions are shaped so as to define an opening through which ions are transmitted axially in use; and
arranging said plurality of plates into an axial stack, wherein the plurality of plates are stacked axially along the length of the ion guiding device in the direction that ions are transmitted in use, and wherein each of the plates and/or each of the electrically conductive portions are individually mounted between a pair of spaced-apart support plates so that said first AC or RF voltage can be applied via only one of said spaced-apart support plates and said second AC or RF voltage can be applied via only the other of said spaced-apart support plates.

9. A method as claimed in claim 8 , wherein said first electrically conductive portions and said second electrically conductive portions are separately formed, and wherein arranging said plurality of plates into an axial stack comprises interleaving said first and second electrically conductive portions.

10. A method as claimed in claim 9 , wherein said first and second electrically conductive portions are formed using a metal injection moulding process.

11. A method as claimed in claim 8 , wherein providing said plurality of plates comprises printing said first and second electrically conductive portions onto a substrate.

12. A method of guiding ions, comprising:
providing an ion guiding device as claimed in claim 1 ;
applying a first AC or RF voltage to said first electrically conductive portions and applying a second AC or RF voltage to said second electrically conductive portions to confine ions within said ion guiding device; and
passing ions through said ion guiding device.

13. A method as claimed in claim 12 , wherein the step of passing ions through said ion guiding device comprises driving or urging ions through said ion guiding device using one or more DC voltages or fields, and optionally using one or more transient DC voltages or potentials.

14. A method of mass or ion mobility spectrometry comprising a method as claimed in claim 13 .

Assignees

• Micromass Ltd

Inventors

• Slater Stephen Patrick
• Iveson John
• Malpas Oliver John
• Chande Bharat
• Gordon David

Classifications

• H01J49/022

  Circuit arrangements, e.g. for generating deviation currents or voltages (regulating electric or magnetic variables in general, e.g. current, magnetic field G05F); Components associated with high voltage supply (high voltage supply per se H02M) · CPC title

• H01J49/063

  Multipole ion guides, e.g. quadrupoles, hexapoles · CPC title

• H01J49/065 Primary

  having stacked electrodes, e.g. ring stack, plate stack · CPC title

• H01J49/4235

  Stacked rings or stacked plates · CPC title