Delivery of biomolecules to immune cells
US-2018142198-A1 · May 24, 2018 · US
Intracellular delivery
US10696944B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10696944-B2 |
| Application number | US-201214352354-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 17, 2012 |
| Priority date | Oct 17, 2011 |
| Publication date | Jun 30, 2020 |
| Grant date | Jun 30, 2020 |
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Abstract
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A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
First claim
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What is claimed is: 1. A method for delivering a payload into a cell, the method comprising: providing a cell in a suspension solution; passing the solution through a microfluidic channel that includes a cell-deforming constriction, wherein a diameter of the constriction is 20-99% of a diameter of the cell in the suspension solution such that a deforming force is applied to the cell as it passes through the constriction thereby causing perturbations of the cell large enough for…
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Frequently asked questions
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- What does patent US10696944B2 cover?
- A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
- Who is the assignee on this patent?
- Massachusetts Inst Technology, Sharei Armon R, Adamo Andrea, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12M23/16. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 30 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).