IL2R common gamma chain antibodies

Patent metadata

Field	Value
Publication number	US-10696747-B2
Application number	US-201816112008-A
Country	US
Kind code	B2
Filing date	Aug 24, 2018
Priority date	Aug 6, 2015
Publication date	Jun 30, 2020
Grant date	Jun 30, 2020

Abstract

Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

First claim

The invention claimed is:

1. An isolated antibody or antigen binding fragment which specifically binds to common γ chain (γc), and comprises:
(i) a light chain variable region comprising the following CDRs:

LC-CDR1:

(SEQ ID NO: 68)

RSSQSLLHSNGYNYLD

LC-CDR2:

(SEQ ID NO: 69)

LGSNRDS

LC-CDR3:

(SEQ ID NO: 70)

MQGTHWPWT;

and
(ii) a heavy chain variable region comprising the following CDRs:

HC-CDR1:

(SEQ ID NO: 48)

GYYWS

HC-CDR2:

(SEQ ID NO: 49)

EINHSGSTNYNPSLKS

HC-CDR3:

(SEQ ID NO: 77)

SPGGYSGGYFQH.

2. The isolated antibody or antigen binding fragment according to claim 1 , wherein:
the light chain variable region sequence has at least 70% sequence identity to SEQ ID NO:67, and
the heavy chain variable region sequence has at least 70% sequence identity to SEQ ID NO:76.

3. The isolated antibody or antigen binding fragment according to claim 1 , wherein:
the light chain variable region sequence has at least 85% sequence identity to SEQ ID NO:67, and
the heavy chain variable region sequence has at least 85% sequence identity to SEQ ID NO:76.

4. The isolated antibody or antigen binding fragment according to claim 1 , conjugated to a drug moiety or a detectable moiety.

5. A bispecific antibody comprising the antibody or antigen binding fragment of claim 1 .

Assignees

• Agency Science Tech & Res

Inventors

• Wang Cheng-I
• Brauer Peter
• Yeo Siok Ping
• Tan Hwee Ching
• CONNOLLY John Edward

Classifications

• C07K16/112

  Retroviridae (F), e.g. leukemia viruses · CPC title

• C12N5/0646

  Natural killers cells [NK], NKT cells · CPC title

• C12N5/0636

  T lymphocytes · CPC title

• A61K39/3955

  against proteinaceous materials, e.g. enzymes, hormones, lymphokines · CPC title

• C07K16/2866 Primary

  against receptors for cytokines, lymphokines, interferons · CPC title