Segmented metallic guidewires

Patent metadata

Field	Value
Publication number	US-10695540-B2
Application number	US-201515514744-A
Country	US
Kind code	B2
Filing date	Oct 19, 2015
Priority date	Oct 20, 2014
Publication date	Jun 30, 2020
Grant date	Jun 30, 2020

Abstract

Disclosed herein are embodiments of segmented metallic guidewires that are suitable for MRI catheterization. Disclosed guidewires comprise a plurality of short conductive metallic segments that individually are short enough such that they do not resonate during MRI. The conductive segments are electrically insulated from each other and mechanically coupled together end-to-end via connectors, such as stiffness matched connectors, to provide a sufficiently long, strong, and flexible guidewire for catheterization that is non-resonant during MRI.

First claim

The invention claimed is:

1. A segmented guidewire for use in medical applications, comprising:
a plurality of elongated metallic rods positioned in axial, end-to-end alignment along a longitudinal axis of the guidewire;
a polymeric insulation layer that surrounds the metallic rods and separates adjacent axial ends of the metallic rods such that the metallic rods are electrically insulated from one another;
a plurality of tubular metallic connectors, each connector being positioned around the insulation layer at a joint between two adjacent axial ends of two of the insulated metallic rods such that the connector overlaps the insulation layer and the two adjacent axial ends of the two metallic rods and secures the two metallic rods together without electrically coupling the two metallic rods together; and
an outer layer comprising polymeric material that is positioned around the polymeric insulation layer and between axial ends of the connectors, such that the segmented guidewire has a uniform outer diameter that is defined by the connectors and the outer layer.

2. The guidewire of claim 1 , wherein the metallic rods and the connectors are stiffness matched.

3. The guidewire of claim 2 , wherein the connectors have an axial length that is less than a radius of curvature that results in plastic deformation of the metallic rods.

4. The guidewire of claim 1 , wherein the polymeric insulation layer comprises a thermoset polymer.

5. The guidewire of claim 1 , wherein inner surfaces of the connectors are adhesively secured to outer surfaces of the polymeric insulation layer.

6. The guidewire of claim 1 , wherein the connectors each comprise two opposing axial ends, wherein each axial end of the connectors comprises an annular rim that includes a plurality of notches, and wherein the outer layer extends into the plurality of notches.

7. The guidewire of claim 1 , wherein the metallic rods include grooves adjacent to the axial ends of the metallic rods and the connectors project radially inwardly into the grooves to mechanically secure the connectors to the metallic rods.

8. The guidewire of claim 7 , wherein the connectors are crimped into the grooves in the metallic rods.

9. The guidewire of claim 1 , wherein the outer layer comprises a braided polymeric outer layer.

10. A method comprising performing magnetic resonance imaging on a portion of a subject while the guidewire of claim 1 is partially or completely inside the portion of the subject.

11. The guidewire of claim 1 , wherein the connectors comprise electrically non-conductive material.

12. The guidewire of claim 1 , wherein the outer layer does not overlap the connectors.

13. The guidewire of claim 1 , wherein the outer layer and the connectors have an equal inner diameter.

14. The guidewire of claim 1 , wherein the insulation layer has a uniform outer diameter.

15. A segmented guidewire for use in medical applications, comprising:
a plurality of elongated metallic rods positioned in axial, end-to-end alignment along a longitudinal axis of the guidewire, wherein each of the metallic rods are electrically insulated from one other; and
a plurality of metallic connectors, each connector positioned at a joint between two adjacent axial ends of two of the insulated metallic rods such that each connector secures the two metallic rods together; and
wherein the metallic rods and the connectors are stiffness matched, such that an axial length of the connectors is shorter than a radius of curvature that achieves plastic deformation of the rods.

16. The guidewire of claim 15 , wherein the connectors are tubular.

17. The guidewire of claim 15 , wherein the metallic rods and the connectors are made of the same metallic material.

18. The guidewire of claim 17 , wherein the metallic rods and the connectors are made of nitinol.

19. The guidewire of claim 15 , wherein the metallic rods and the connectors are made of different metallic materials.

20. The guidewire of claim 19 , wherein the metallic rods are made of nitinol and the connectors are made of titanium or paramagnetic stainless steel.

21. The guidewire of claim 15 , wherein at least some of the metallic rods are covered with a polymeric insulation layer that provides electrical insulation between adjacent metallic rods.

22. The guidewire of claim 21 , wherein the polymeric insulation layer comprises an inner polymeric insulation layer, the guidewire further comprising an outer polymeric layer positioned over the inner polymeric insulation layer.

23. The guidewire of claim 22 , wherein the connectors include at least one axial end that comprises an annular rim that includes a plurality of notches extending circumferentially around a metallic rod, and the outer polymeric layer fills in the notches.

24. The guidewire of claim 15 , wherein the metallic rods and the connectors are covered by a non-metallic braided polymeric outer layer.

25. The guidewire of claim 15 , wherein the axial length of the connectors is less than 7 mm.

26. A segmented guidewire for use in medical applications, comprising:
a plurality of elongated metallic rods positioned in axial, end-to-end alignment along a longitudinal axis of the guidewire; and
a plurality of metallic connectors, each connector positioned at a joint between two adjacent axial ends of two of the metallic rods, wherein each of the connectors has a first axial end that is adhesively bonded to an electrically insulated end portion of one of the metallic rods such that the metallic rod is electrically insulated from the first axial end of the connector, and wherein each connector has a second axial end that is welded to an uninsulated end portion of another of the metallic rods, such that the connector secures the two metallic rods together by both adhesion and welding without electrically coupling the two metallic rods together;
wherein the first axial end of each connector comprises an annular rim that includes a plurality of notches that extend circumferentially around the insulated end portion of the metallic rod, and the metallic rod is covered with a polymeric jacket that fills in the plurality of notches in the annular rim of the connector.

27. The guidewire of claim 26 , wherein the metallic rods and the connectors are stiffness matched and the connectors have an axial length that is less than a radius of curvature that results in plastic deformation of the metallic rods.

28. The guidewire of claim 26 , wherein the first axial end of the connector is tubular and overlaps the insulated end portion of one of the metallic rods.

29. The guidewire of claim 26 , wherein the second axial end of the connector is tubular and overlaps the uninsulated end portion of the metallic rod that is welded to the connector.

30. The guidewire of claim 26 , wherein the segmented guidewire has a uniform outer diameter that is defined by the connectors and the polymeric jacket, which have equal outer diameters.

Assignees

• Us Health

Inventors

• Kocaturk Ozgur
• Basar Burcu
• Lederman Robert J

Classifications

• G01R33/286

  involving passive visualization of interventional instruments, i.e. making the instrument visible as part of the normal MR process · CPC title

• G01R33/3685

  Means for reducing sheath currents, e.g. RF traps, baluns · CPC title

• G01R33/288

  Provisions within MR facilities for enhancing safety during MR, e.g. reduction of the specific absorption rate [SAR], detection of ferromagnetic objects in the scanner room · CPC title

• A61M25/09 Primary

  Guide wires · CPC title

• A61M2025/09075

  having a core without a coil possibly combined with a sheath · CPC title