Methods of determining energy balance using breath carbon isotope ratios

Patent metadata

Field	Value
Publication number	US-10694993-B2
Application number	US-201816058059-A
Country	US
Kind code	B2
Filing date	Aug 8, 2018
Priority date	Jan 10, 2014
Publication date	Jun 30, 2020
Grant date	Jun 30, 2020

Abstract

Described herein are methods of determining energy balance in individuals such as exercising individuals, individuals consuming a 13C-enriched test composition and individuals consuming a fixed diet with a known δ13C. The δ13C pre- and post-exercise, or pre- and post-consumption of the test beverage or fixed diet indicate whether the individual is in neutral or positive energy balance, or in energy deficit. The methods are particularly useful for individuals participating in weight management programs, and individuals under the care of health care professionals.

First claim

The invention claimed is:

1. A method of administering a diet to a non-infected exercising individual or exercising the non-infected exercising individual, comprising
obtaining a pre-exercise breath sample from the individual, wherein the individual is a participant in a weight-loss program consuming an energy-restricted diet;
exercising the individual for a period of time, wherein exercise is aerobic exercise that causes a temporary increase in respiration and heart rate;
obtaining a post-exercise breath sample from the individual, wherein the post-exercise breath sample is taken within 1 minute to 5 hours after completion of exercise;
measuring a δ 13 C of the pre-exercise breath sample and a δ 13 C of the post-exercise breath sample using cavity ringdown spectroscopy; and
administering a diet with a reduced calorie intake to the individual or increasing exercise in the individual when the individual is determined to be at neutral or positive energy balance post-exercise, or continuing administering the energy-restricted diet when the individual is determined to be in energy deficit post-exercise,
wherein an increased post-exercise δ 13 C compared to the pre-exercise δ 13 C indicates that the individual is at neutral or positive energy balance, and a constant post-exercise δ 13 C compared to the pre-exercise δ 13 C indicates that the individual is in energy deficit, and
wherein the increased post-exercise δ 13 C is greater than or equal to 0.7% during neutral or positive energy balance, and the constant post-exercise δ 13 C is increased less than 0.7% in energy deficit.

2. The method of claim 1 , wherein the individual is determined to be at neutral or positive energy balance post-exercise, and the method comprises administering a diet with a reduced calorie intake to the individual.

3. The method of claim 1 , wherein the individual is determined to be at neutral or positive energy balance post-exercise, and the method comprises increasing exercise in the individual.

4. The method of claim 1 , wherein the individual is determined to be in energy deficit post-exercise, and the method comprises continuing administering the energy-restricted diet to the individual.

5. The method of claim 1 , wherein the exercise is less than one hour in duration.

6. A method of administering a diet to a non-infected exercising individual or exercising the non-infected exercising individual comprising
obtaining a pre-exercise breath sample from the individual, wherein the individual is in need of body mass increase and is consuming an energy-excess diet;
exercising the individual for a period of time, wherein exercise is aerobic exercise that causes a temporary increase in respiration and heart rate;
obtaining a post-exercise breath sample from the individual, wherein the post-exercise breath sample is taken within 1 minute to 5 hours after completion of exercise;
measuring a δ 13 C of the pre-exercise breath sample and a δ 13 C of the post-exercise breath sample using cavity ringdown spectroscopy, and
administering a diet with an increase in calorie intake to the individual or decreasing exercise in the individual when the individual is determined to be in energy deficit, and continuing administering the energy-excess diet when the individual is determined to be in neutral or positive energy balance post-exercise,
wherein an increased post-exercise δ 13 C compared to the pre-exercise δ 13 C indicates that the individual is at neutral or positive energy balance post-exercise, and a constant post-exercise δ 13 C compared to the pre-exercise δ 13 C indicates that the individual is in energy deficit, and
wherein the increased post-exercise δ 13 C is greater than or equal to 0.7% during neutral or positive energy balance, and the constant post-exercise δ 13 C is increased less than 0.7% in energy deficit.

7. The method of claim 6 , wherein the individual is determined to be in energy deficit post-exercise, and the method comprises administering a diet with an increased calorie intake to the individual.

8. The method of claim 6 , wherein the individual is determined to be in energy deficit post-exercise, and the method comprises decreasing exercise in the individual.

9. The method of claim 6 , wherein the individual is determined to be in neutral or positive energy balance post-exercise, and the method comprises continuing administering the energy-excess diet to the individual.

10. The method of claim 6 , wherein the exercise is less than one hour in duration.

Assignees

• Wisconsin Alumni Res Found
• Us Agriculture

Inventors

• Butz Daniel Elmer
• Whigham Leah D
• Cook Mark E
• Porter Warren Paul
• Abbott David H
• Schoeller Dale A

Classifications

• G01N33/497

  of gaseous biological material, e.g. breath · CPC title

• A61K41/0028

  Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds · CPC title

• A61B5/4866

  Evaluating metabolism (using breath test A61B5/083) · CPC title

• A61B5/486 Primary

  Biofeedback (using electroencephalography [EEG] A61B5/375) · CPC title

• A61K49/0004

  Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions · CPC title