Apparatus and method for sensing biomolecules which allows restoration of sensing offset

Patent metadata

Field	Value
Publication number	US-10690582-B2
Application number	US-201715698646-A
Country	US
Kind code	B2
Filing date	Sep 8, 2017
Priority date	Sep 9, 2016
Publication date	Jun 23, 2020
Grant date	Jun 23, 2020

Abstract

An apparatus for sensing biomolecules includes: a storage in which a solution containing a target material is received; a sensor configured to sense the target material; and a flow controller connected between the storage and the sensor to supply the solution to the sensor, wherein the flow controller controls a solution flow to supply the solution containing the target material and the solution containing no target material in an alternating manner. According to the apparatus for sensing biomolecules, the sensing device always achieves a sensing offset, and consequently, long-term continuous measurement is enabled, leading to the maximized usage efficiency of the sensor, and the value of quantitative measurement can be obtained with high precision.

First claim

What is claimed is:

1. An apparatus for sensing biomolecules, comprising:
a storage in which a solution containing a target material is received;
a sensor configured to sense the target material; and
a flow controller comprising:
a first flow path connecting the storage and the sensor;
a second flow path connecting the storage and the sensor;
a filter installed on the second flow path and not on the first flow path, the filter filtering out the target material,
wherein the flow controller controls a solution flow to supply the solution containing the target material through the first flow path and a solution containing no target material through the second flow path to the sensor in an alternating manner, and
the first flow path and the second flow path are connected to each other into a single path extending to the sensor.

2. The apparatus for sensing biomolecules according to claim 1 , wherein the flow controller further comprises:
a first valve installed on the first flow path, wherein the first valve is opened and closed to control a flow of the solution containing the target material received from the storage; and
a second valve installed between the filter of the second flow path and the sensor, wherein the second valve is opened and closed to control a flow of the solution containing no target material.

3. The apparatus for sensing biomolecules according to claim 2 , wherein the flow controller is configured to open the first valve and the second valve in an alternating manner at a preset time interval.

4. The apparatus for sensing biomolecules according to claim 3 , wherein the preset time interval comprises 5 to 20 minutes.

5. The apparatus for sensing biomolecules according to claim 2 , wherein the filter includes a filtration device configured to filter out the target material based on particle size.

6. The apparatus for sensing biomolecules according to claim 2 , wherein the filter includes an adsorption device to which the target material specifically binds and which prevents the target material from passing through the filter.

Assignees

• Korea Inst Sci & Tech

Inventors

• CHOI Jaebin
• Kim Chulki
• Kim Sang Kyung
• Lee Seok
• Lim Chaehyun
• Kim Jae Hun
• Lee Taikjin
• Seo Minah

Classifications

• G01N35/1095

  for supplying the samples to flow-through analysers (for a specific analyser see relevant groups, e.g. under G01N15/00, G01N21/00, G01N27/00, G01N30/00, H01J49/00) · CPC title

• G01N2015/0053

  in liquids, e.g. trouble · CPC title

• G01N15/0656 Primary

  using electric, e.g. electrostatic methods or magnetic methods (by investigating individual particles G01N15/1031, G01N15/12) · CPC title

• G01N2015/0038

  Investigating nanoparticles · CPC title

• G01N33/48785

  Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply · CPC title