Devices, systems and methods for magnetic-assisted therapeutic agent delivery

Patent metadata

Field	Value
Publication number	US-10688292-B2
Application number	US-201213684521-A
Country	US
Kind code	B2
Filing date	Nov 24, 2012
Priority date	Feb 25, 2009
Publication date	Jun 23, 2020
Grant date	Jun 23, 2020

Abstract

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.

First claim

The invention claimed is:

1. A method for directing an agent into or through material, comprising:
positioning a magnetic configuration having a plurality of magnetic elements, wherein the plurality of magnetic elements includes a first magnetic element that produces a first magnetic field and a second magnetic element that produces a second magnetic field; the first magnetic field and the second magnetic field overlap to create a combined field and a node that is a local magnetic field strength minimum, wherein the combined field is configured to push the agent away from the first magnetic element and the second magnetic element; the first magnetic element and the second magnetic element are arranged at an angle greater than zero degrees to define a central space between the first magnetic element and the second magnetic elements, wherein the central space is defined by a physical space between the first magnetic element and the second magnetic element that includes a least volume enclosed by a minimal convex shape that includes all material points of the first magnetic element and the second magnetic element; and
pushing the agent with the combined field into or through the material away from the central space.

2. The method as claimed in claim 1 , wherein the agent is magnetic, superparamagnetic, ferrimagnetic, ferromagnetic, or paramagnetic.

3. The method as claimed in claim 1 , further comprising: associating a non-magnetic material with the agent.

4. The method as claimed in claim 1 , further comprising: depositing the agent onto a tissue.

5. The method as claimed in claim 1 , further comprising:
adjusting the angle between the first magnetic element and the second magnetic element.

6. The method as claimed in claim 1 , further comprising: calculating a desired angle between the first magnetic element and the second magnetic element to position the local magnetic field strength minimum at a desired location; and adjusting the angle between the first magnetic element and the second magnetic elements to the desired angle.

7. The method as claimed in claim 1 , further comprising: varying the angle between the first magnetic element and the second magnetic element to maintain the local magnetic field strength minimum directly behind the agent so to push the agent.

8. The method as claimed in claim 1 , wherein either the first magnetic field or the second magnetic field has a field strength of about 1 micro-Tesla to about 8 Tesla.

9. A method for administering an agent to a treatment site, comprising:
applying the agent at a distance from the treatment site, wherein the agent is magnetic or magnetizable; and
pushing the agent to the treatment site with a magnetic configuration having a plurality of magnetic elements, wherein the plurality of magnetic elements includes a first magnetic element that produces a first magnetic field and a second magnetic element that produces a second magnetic field; the first magnetic field and the second magnetic field overlap to create a combined field and a node that is a local magnetic field strength minimum; wherein the combined field is configured to act on the agent to push the agent away from the first magnetic element and the second magnetic element; the first magnetic element and the second magnetic element are arranged at an angle greater than zero degrees to define a central space between the first magnetic element and the second magnetic element; wherein the central space is defined by a physical space between the first magnet element and the second magnetic element that includes a least volume enclosed by a minimal convex shape, wherein the minimal convex shape includes all material points of the first magnetic element and the second magnetic elements.

10. A device for directing an agent that is magnetic or magnetizable, comprising: a plurality of permanent magnetic elements, wherein the plurality of magnetic elements includes a first magnetic element that produces a first magnetic field and a second magnetic element that produces a second magnetic field; the first magnetic field and the second magnetic field overlap to create a combined magnetic field and a node that is a local magnetic field strength minimum, wherein the combined magnetic field is configured to push the agent away from the first magnetic element and the second magnetic element; the first magnetic element and the second magnetic element define a central space between the first magnetic element and the second magnetic element are arranged at an angle greater than zero degrees; wherein the central space is a physical space between the first magnetic element and the second magnetic element that includes a least volume enclosed by a minimal convex shape that includes all material points of the first magnetic element and the second magnetic element.

11. The devices as claimed in claim 10 , wherein the combined magnetic field repels the agent, the agent being magnetic, superparamagnetic, ferrimagnetic, ferromagnetic, or paramagnetic.

12. The device as claimed in claim 10 , wherein the agent is diamagnetic.

13. The device as claimed in claim 10 , wherein the angle is adjustable.

14. The device as claimed in claim 10 , wherein the first magnetic field and the second magnetic field are static fields.

15. A system for directing an agent into or through tissue, comprising:
an agent that is magnetic or magnetizable; and
a magnetic configuration having a plurality of magnetic elements, wherein the plurality of magnetic elements includes a first magnetic element that produces a first magnetic field and a second magnetic that produces a second magnetic field; the first magnetic field and the second magnetic field overlap to create a combined magnetic field and a node that is a local magnetic field strength minimum; the first magnetic element and the second magnetic element are arranged at an angle greater than zero degrees to define a central space between the first magnetic element and the second magnetic element; wherein the central space is a physical space between the first magnetic element and the second magnet element that includes a least volume enclosed by a minimal convex shape that includes all material points of the first magnetic element and the second magnetic element; and wherein the combined magnetic field is configured to push the agent away from the central space.

16. The system as claimed in claim 15 , wherein the first magnetic element or the second magnetic element is electromagnetic.

17. The system as claimed in claim 15 , wherein the first magnetic field or the second magnetic field has a strength of about 1 micro-Tesla to about 8 Tesla.

18. The system as claimed in claim 15 , wherein the angle is adjustable.

19. The system as claimed in claim 15 , wherein the first magnetic field and the second magnetic field are static fields.

Assignees

• Shapiro Benjamin
• Rutel Isaac B
• Univ Maryland

Inventors

• Shapiro Benjamin
• Rutel Isaac B

Classifications

• A61M37/0092 Primary

  using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis · CPC title

• A61M2037/0007

  having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents · CPC title

• A61M37/00 Primary

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title