Methods and devices for skin closure

Patent metadata

Field	Value
Publication number	US-10687986-B2
Application number	US-201715675159-A
Country	US
Kind code	B2
Filing date	Aug 11, 2017
Priority date	Sep 29, 2016
Publication date	Jun 23, 2020
Grant date	Jun 23, 2020

Abstract

A wound closure device and a method of its use are disclosed. The wound closure device comprises a wound closure strip, the wound closure strip comprising a wound-facing side and a top side, the wound-facing side comprises an adhesive applied over at least a portion of the wound facing side of the wound closure strip and a non-symmetric, two-part release liner assembly detachably adhered to the adhesive, the release liner assembly comprising a first section and a second section with the second section comprising a wound closure strip-free portion forming a tab. In an alternate embodiment, the device is multi-segmented and the wound closure strip may be coextensive with the release liner assembly.

First claim

What is claimed is:

1. A multi-segmented wound closure device having an overall length A′, a width B, an upper edge, a lower edge, a right-hand edge, and a left-hand edge with each segment of the device comprising:
a wound closure strip having a length A, a width F, a wound-facing side, a top side, an upper edge and a lower edge, the wound-facing side comprising an adhesive applied over at least a portion of the wound facing side;
a release liner assembly detachably adhered to the wound closure strip by the adhesive, the release liner assembly consisting of a first section having a length A and a width E and a second section having a length A and a width D;
wherein the release liner assembly extends the full length A of each segment of the wound closure device and extends the full width B of the wound closure device, wherein the release liner assembly optionally forms a wound closure strip-free tab, wherein the wound closure strip-free tab has a width of G extending from the lower edge of the wound closure device to the lower edge of the wound closure strip;
wherein the width F of the wound closure strip is greater than the width E of the first section by a width H, where H is equal to length D minus width G; and
wherein the first section and the second section are separated from each other by a liner cut.

2. The wound closure device of claim 1 wherein:
the wound closure strip is porous;
the length A′ is from 2 to 20 cm and the width B from 1.7 to 12 cm;
the wound closure strip has a width F extending from the upper edge of the wound closure device and where F is from 1.5 to 8 cm;
the wound closure strip-free tab has a width G of 0.2 to 4.0 cm;
the first section of the release liner assembly has a width of E extending from the upper edge of the wound closure device and is from 1.5 to 8.0 cm and the second section of the release liner assembly has a width D extending from the lower edge of the wound closure device is from 0.2 to 4 cm such that the width E of the first section is greater than the width D of the second section; and
the width B of the device is equal to the width E of the first section plus the width D of the second section.

3. The wound closure device of claim 1 , wherein each segment of the wound closure device has a length of 1-8 cm.

4. The wound closure device of claim 3 , wherein there is no wound closure strip-free tab.

5. The wound closure device according to any one of claims 1 - 4 , wherein the wound closure strip is a mesh.

6. The wound closure device according to any one of claims 1 - 4 , wherein the adhesive is provided over the entire wound-facing side of the wound closure strip.

7. The wound closure device according to any one of the claims 1 - 4 , wherein the adhesive is a medical grade adhesive is selected from acrylic based pressure sensitive adhesives (PSAs), rubber based pressure sensitive adhesives, silicone pressure sensitive adhesives and mixtures thereof.

8. The wound closure device of any one of the claims 1 - 4 wherein the wound closure strip includes at least a polymerization initiator or rate modifier.

9. A kit comprising:
(a) the wound closure device of any one of the claims 1 - 4 ; and
(b) a polymerizable adhesive composition for application over the wound closure strip after the wound closure strip has been applied to a tissue or wound site.

10. The kit according to claim 9 , wherein the polymerizable adhesive composition is different than the adhesive applied to the wound facing side of the wound closure strip.

11. A method of closing a wound having at least a first separated topical tissue surface and a second separated topical tissue surface comprising the steps of:
a) utilizing the device of any one of the claims 1 - 4 and separating a segment of the multi-segmented device;
b) removing the first section of the release liner assembly to expose a portion of the wound facing side of the wound closure strip while grasping the tab of the second section of the release liner assembly;
c) adhering a portion of the exposed wound facing side of the wound closure strip to the at least first separated topical tissue surface and pulling the tab of the second section of the release liner toward the at least second separated topical tissue surface to form two abutted topical tissue surfaces and further adhering the exposed wound facing side of the wound closure strip to the at least second topical tissue surface; and
d) removing the second section of the release liner assembly to further expose a wound facing side of the wound closure strip and adhering the further exposed wound closure strip the second topical tissue surface.

12. The method of claim 11 , further comprising the step of applying a flowable, polymerizable adhesive over the wound closure strip.

13. The method of claim 12 , wherein the wound closure strip comprises a mesh.

14. The method of claim 13 , when the mesh comprises materials selected form the group consisting of polyesters, polyolefins and polyamides.

15. The method of claim 14 , wherein the flowable, polymerizable adhesive comprises a polymerizable 1,1-disubstituted ethylene monomer.

16. The method of claim 15 , wherein the flowable, polymerizable adhesive comprises an α-cyanoacrylate monomer.

17. The method of claim 16 , wherein the mesh further comprises an initiator.

18. The method of claim 17 , wherein the initiator is selected from the group consisting of benzalkonium and benzyltrialkyl ammonium halides.

19. The method of claim 18 wherein the initiator is benzalkonium chloride.

20. The method of claim 19 wherein the adhesive is an acrylic based pressure sensitive adhesive.

Assignees

• Ethicon Inc

Inventors

• Quintero Julian

Classifications

• A61L15/22

  containing macromolecular materials · CPC title

• A61F2013/00817

  handles or handling tabs · CPC title

• A61F2013/00459

  with cyano-acrylic adhesive · CPC title

• A61F2013/00451

  for surgical sutures, e.g. butterfly type · CPC title

• A61F2013/00238

  characterised by way of knitting or weaving · CPC title